The goal of this review is to provide further understanding of increased vascular stiffness
with aging, and how it contributes to the adverse effects of major human diseases …

Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality in both
men and women in developed societies. Age is the greatest risk factor for CVD due largely …

Background: Unlike heart failure with reduced ejection fraction, there is no approved
treatment for heart failure with preserved ejection fraction, the predominant phenotype in …

Estrogen is a pivotal signaling molecule; its production is regulated by the expression of the
aromatase (CYP19A1) gene from ovarian and peripheral tissue sites, and it is transmitted …

Objective: Postmenopausal women exhibit elevated brachial-ankle pulse wave velocity
(baPWV), an indicator of arterial stiffness, which is associated with an increased risk of …

Women become depressed more frequently than men, a consistent pattern across cultures.
Inflammation plays a key role in initiating depression among a subset of individuals, and …

Menopausal disorders may include shorter-term symptoms, such as hot flushes and night
sweats (vasomotor symptoms, VMS) and longer-term chronic conditions such as …

Despite significant decreases in cardiovascular disease (CVD) mortality in the past three
decades, it still remains the leading cause of death in women. Following menopause and …

Background Although the association between menopause and cardiovascular disease
(CVD) risk has been studied extensively, the simultaneous role of chronological aging …

Diabetes is a worldwide health issue closely associated with cardiovascular events. Given
the pandemic of obesity, the identification of the basic underpinnings of vascular disease is …