Abstract Streptozotocin (STZ), a glucosamine-nitrosourea compound derived from soil
bacteria and originally developed as an anticancer agent, in 1963 has been found to induce …

Diabetes often leads to a number of complications involving brain function, including
cognitive decline and depression. In addition, depression is a risk factor for developing …

It is now well established that the mammalian brain has the capacity to produce new
neurons into adulthood. One such region that provides the proper milieu to sustain …

Curcuma longa is a major constituent of Xiaoyao-san, the traditional Chinese medicine,
which has been used to effectively manage stress and depression-related disorders in …

Diabetes mellitus is the most common metabolic disease, and its prevalence is increasing. A
growing body of evidence, both in animal models and epidemiological studies, has …

Cognitive dysfunction and dementia have recently been proven to be common (and
underrecognized) complications of diabetes mellitus (DM). In fact, several studies have …

Previously we have demonstrated that a Rhodiola crenulata extract (RCE), containing a
potent antioxidant salidroside, promotes neurogenesis in the hippocampus of depressive …

Type 1 diabetes (T1D) is accompanied by a “diabetic encephalopathy” including
hypersensitivity to stress, increased risk of stroke, dementia and cognitive impairment. In …

Stroke is devastating as currently no therapies are available that can prevent stroke-induced
neurological dysfunction in humans. With the recent observations that acute insults to adult …

Objectives–Adult neurogenesis in dentate gyrus (DG) is an evolutionarily preserved trait in
most mammals examined thus far. Neuronal proliferation and subsequent integration of new …