RNA has triggered a significant shift in modern medicine, providing a promising way to
revolutionize disease treatment methods. Different therapeutic RNA modalities have shown …

Metabolic dysfunction‐associated diseases often refer to various diseases caused by
metabolic problems such as glucose and lipid metabolism disorders. With the improvement …

Oligonucleotide therapeutics (ASOs and siRNAs) have been explored for modulation of
gene expression in the central nervous system (CNS), with several drugs approved and …

A surge in the approval of therapeutic oligonucleotides since 2016 has made this class of
chemical modalities an essential toolbox for addressing unmet medical needs in the realm …

Cationic polymers are known to efficiently deliver nucleic acids to target cells by
encapsulating the cargo into nanoparticles. However, the molecular organization of these …

The coronavirus pandemic has resulted in over 775 million cases and 7 million deaths
worldwide, driving efforts to develop therapeutic strategies to control the viral infection …

Abstract Purpose of the Review Osteosarcopenia is a geriatric syndrome associated with
disability and mortality. This review summarizes the key microRNAs that regulate the …

This review highlights the potential of asialoglycoprotein receptor (ASGPR)-mediated
targeting in advancing liver-specific treatments and underscores the ongoing progress in the …

Abstract Hydrophilic Interaction Liquid Chromatography (HILIC) and Mixed-Mode
Chromatography (MMC) excel in separating polar, hydrophilic, and charged analytes due to …

Introduction Antisense oligonucleotide (ASO) was established as a viable therapeutic option
for genetic disorders. ASOs can target RNAs implicated in various diseases, including …