Therapeutic nanoparticles and their targeted delivery applications

AA Yetisgin, S Cetinel, M Zuvin, A Kosar, O Kutlu - Molecules, 2020 - mdpi.com
Nanotechnology offers many advantages in various fields of science. In this regard,
nanoparticles are the essential building blocks of nanotechnology. Recent advances in …

Metabolic orchestration of the wound healing response

SA Eming, PJ Murray, EJ Pearce - Cell metabolism, 2021 - cell.com
Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

[HTML][HTML] The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

J Friščić, M Böttcher, C Reinwald, H Bruns, B Wirth… - Immunity, 2021 - cell.com
Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Role of lactate in inflammatory processes: friend or foe

C Manosalva, J Quiroga, AI Hidalgo, P Alarcón… - Frontiers in …, 2022 - frontiersin.org
During an inflammatory process, shift in the cellular metabolism associated with an increase
in extracellular acidification are well-known features. This pH drop in the inflamed tissue is …

The pathogenesis of rheumatoid arthritis

IB McInnes, G Schett - New England Journal of Medicine, 2011 - Mass Medical Soc
The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

A Smart Nanoreactor Based on an O2-Economized Dual Energy Inhibition Strategy Armed with Dual Multi-stimuli-Responsive “Doorkeepers” for Enhanced CDT/PTT …

S Qiu, X Wu, Z Li, X Xu, J Wang, Y Du, W Pan… - ACS …, 2022 - ACS Publications
Activated fibroblast-like synovial (FLS) cells are regarded as an important target for
rheumatoid arthritis (RA) treatment via starvation therapy mediated by glucose oxidase …

Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis

Q Cheng, M Chen, M Liu, X Chen, L Zhu, J Xu… - Cell death & …, 2022 - nature.com
Abnormal activation of synovial fibroblasts (SFs) plays an important role in rheumatoid
arthritis (RA), the mechanism of which remains unknown. The purpose of our study is to …

[HTML][HTML] Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management

J Wen, H Li, H Dai, S Hua, X Long, H Li, S Ivanovski… - Materials Today Bio, 2023 - Elsevier
Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic and progressive inflammatory
joint diseases that affect a large population worldwide. Intra-articular administration of …

Three hematologic/immune system-specific expressed genes are considered as the potential biomarkers for the diagnosis of early rheumatoid arthritis through …

Q Cheng, X Chen, H Wu, Y Du - Journal of translational medicine, 2021 - Springer
Background Rheumatoid arthritis (RA) is the most common chronic autoimmune connective
tissue disease. However, early RA is difficult to diagnose due to the lack of effective …

Icariin enhances cell survival in lipopolysaccharide‑induced synoviocytes by suppressing ferroptosis via the Xc‑/GPX4 axis

H Luo, R Zhang - Experimental and Therapeutic …, 2021 - spandidos-publications.com
The mechanism of action of synovitis, as the vital pathological process of rheumatoid arthritis
and osteoarthritis, remains to be elucidated. The effects and the mechanism of icariin (ICA) …