[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Alginate-based nanocarriers for the delivery and controlled-release of bioactive compounds

A Karim, A Rehman, J Feng, A Noreen… - Advances in colloid and …, 2022 - Elsevier
Alginate-based nanocarriers are propitious vehicles used for the delivery of bioactive
compounds (bioactives). In this area, calcium alginate and sodium alginate are the most …

Nanoemulsion: Concepts, development and applications in drug delivery

Y Singh, JG Meher, K Raval, FA Khan… - Journal of controlled …, 2017 - Elsevier
Nanoemulsions are biphasic dispersion of two immiscible liquids: either water in oil (W/O) or
oil in water (O/W) droplets stabilized by an amphiphilic surfactant. These come across as …

Current approaches in lipid-based nanocarriers for oral drug delivery

M Plaza-Oliver, MJ Santander-Ortega… - Drug Delivery and …, 2021 - Springer
Lipid-based nanocarriers have gained much interest as carriers of drugs with poor oral
bioavailability because of their remarkable advantages like low toxicity, affordable scale-up …

Nanotechnology for increased micronutrient bioavailability

IJ Joye, G Davidov-Pardo, DJ McClements - Trends in food science & …, 2014 - Elsevier
Highlights•Colloidal delivery systems for food applications are created using
nanotechnology.•Edible nanoparticles are made from surfactants, lipids, protein and/or …

Drug nanodelivery systems based on natural polysaccharides against different diseases

A Rehman, SM Jafari, Q Tong, T Riaz… - Advances in Colloid and …, 2020 - Elsevier
Drug nanodelivery systems (DNDSs) are fascinated cargos to achieve outstanding
therapeutic results of various drugs or natural bioactive compounds owing to their unique …

Lipid-based nanocarriers for oral peptide delivery

Z Niu, I Conejos-Sánchez, BT Griffin… - Advanced drug delivery …, 2016 - Elsevier
This article is aimed to overview the lipid-based nanostructures designed so far for the oral
administration of peptides and proteins, and to analyze the influence of their composition …

Nanoparticle delivery systems in the treatment of diabetes complications

EB Souto, SB Souto, JR Campos, P Severino… - Molecules, 2019 - mdpi.com
Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the
homeostasis of blood sugar levels, being the subcutaneous injection of insulin the first line …

Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis

MB Zewail, SA El-Gizawy, GF Asaad… - International Journal of …, 2023 - Elsevier
Rheumatoid arthritis (RA), a distressing inflammatory autoimmune disease, is managed
mainly by Disease-modifying antirheumatic drugs (DMARDs), eg leflunomide (LEF). LEF …

Effects of chitosan coating on curcumin loaded nano-emulsion: Study on stability and in vitro digestibility

J Li, IC Hwang, X Chen, HJ Park - Food Hydrocolloids, 2016 - Elsevier
Nano-emulsion (NE) composed of MCT oil, Tween 80 and lecithin was fabricated by
ultrasonication method to encapsulate curcumin. Loading ability and efficiency of curcumin …