The present advances in biology are related to progress in genomics, proteomics, and other
“-omics”, including glycomics, working with a large amount of data regarding human and …

Surface plasmon resonance (SPR) sensing has long been used to study biomolecular
binding events and their kinetics in a label-free way. This approach has recently been …

The classical method of measuring binding constants with affinity-based biosensors involves
testing several analyte concentrations over the same ligand surface and regenerating the …

The maximum achievable accuracy of in silico models depends on the quality of the
experimental data. Consequently, experimental uncertainty defines a natural upper limit to …

Computational techniques can speed up the identification of hits and accelerate the
development of candidate molecules for drug discovery. Among techniques for predicting …

The NKG2x/CD94 family of C-type lectin-like immunoreceptors (x= A, B, C, E, and H)
mediates surveillance of MHC class Ia cell surface expression, often dysregulated during …

To explore the reliability of Biacore-based assays, 22 study participants measured the
binding of prostate-specific antigen (PSA) to a monoclonal antibody (mAb). Each participant …

Measuring the strength of binding of low molecular weight ligands to a target protein is a
significant challenge to fragment-based drug discovery that must be solved. Thermal shift …

Nucleic acid aptamers function as versatile sensing and targeting agents for analytical,
diagnostic, therapeutic, and gene-regulatory applications, but their limited characterization …

A ProteOn XPR36 parallel array biosensor was used to characterize the binding kinetics of a
set of small molecule/enzyme interactions. Using one injection with the ProteOn's …