It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Parkinson's disease (PD) is a neurological disorder marked by the presence of cytoplasmic
inclusions, Lewy bodies (LBs) and Lewy neurites (LNs) as well as the degeneration of …

Amyloid aggregates found in the brain of patients with neurodegenerative diseases,
including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger …

Cells have evolved complex mechanisms to maintain protein homeostasis, such as the UPR
ER, which are strongly associated with several diseases and the aging process. We …

Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

Amyloidosis is a protein folding disorder in which normally soluble proteins are deposited
extracellularly as insoluble fibrils, impairing tissue structure and function. Charged …

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and prion diseases, are
directly linked to the formation and accumulation of protein aggregates in the brain. These …

The abnormal folding and aggregation of amyloid-β protein (Aβ) is the main reason for the
occurrence and development of Alzheimer's disease (AD). The discovery of novel inhibitors …

The most straightforward applications of proteomics database searching involve intracellular
proteins. Although intracellular gene products number in the thousands, their well-defined …

Immune regulation is a complex biological signaling pathway in which several classes of
biomolecules and small molecules play a complacent role to mediate this process …