Organs-on-a-chip, or OoCs, are microfluidic tissue culture devices with micro-scaled
architectures that repeatedly achieve biomimicry of biological phenomena. They are well …

Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA),
afflict a substantial proportion of the global population. However, current clinical …

Arthritis affects millions of people worldwide. With only a few disease-modifying drugs
available for treatment of rheumatoid arthritis and none for osteoarthritis, a clear need exists …

In recent years, our scientific interest in spaceflight has grown exponentially and resulted in
a thriving area of research, with hundreds of astronauts spending months of their time in …

Obesity and type 2 diabetes are strongly associated with adipose tissue dysfunction and
impaired adipogenesis. Understanding the molecular underpinnings that control …

Conventional preclinical evaluation implemented in 2D monolayer cultures falls short with
multiorgan interactions, while animal systems lack the specificity of the human species …

Soft tissue defects are a common clinical challenge mostly caused by trauma, congenital
anomalies and oncological surgery. Current soft tissue reconstruction options include …

In recent years, the progress of microfluidic technology has provided new tools for
pharmaceutical analysis and the proposal of pharm-lab-on-a-chip is appealing for its great …

Bacterial meningitis, an infection of the membranes (meninges) and cerebrospinal fluid
(CSF) surrounding the brain and spinal cord, is one of the major causes of death and …

The vasculature is an essential, physiological element in virtually all human tissues.
Formation of perfusable vasculature is therefore crucial for reliable tissue modeling. Three …