Vitamin B12 status in health and disease: a critical review. Diagnosis of deficiency and insufficiency – clinical and laboratory pitfalls

A Sobczyńska-Malefora, E Delvin… - Critical reviews in …, 2021 - Taylor & Francis
Vitamin B12 (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained
principally from food of animal origin. Cobalamin becomes bioavailable through a series of …

Risk factors for Alzheimer's disease

RA Armstrong - Folia neuropathologica, 2019 - termedia.pl
Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD)
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …

Microbial production of vitamin B12

JH Martens, H Barg, M Warren, D Jahn - Applied microbiology and …, 2002 - Springer
One of the most alluring and fascinating molecules in the world of science and medicine is
vitamin B 12 (cobalamin), which was originally discovered as the anti pernicious anemia …

What causes Alzheimer's disease?

RA Armstrong - Folia neuropathologica, 2013 - termedia.pl
Since the earliest descriptions of Alzheimer's disease (AD), many theories have been
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …

Vitamin B12 and folate in relation to the development of Alzheimer's disease

HX Wang, A Wahlin, H Basun, J Fastbom, B Winblad… - Neurology, 2001 - AAN Enterprises
Objective: To explore the associations of low serum levels of vitamin B12 and folate with AD
occurrence. Methods: A population-based longitudinal study in Sweden, the Kungsholmen …

Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage

PI Ho, D Ortiz, E Rogers… - Journal of neuroscience …, 2002 - Wiley Online Library
Homocysteine (HC) is a neurotoxic amino acid that accumulates in several neurological
disorders including Alzheimer's disease (AD). We examined the consequences of treatment …

Total serum homocysteine in senile dementia of Alzheimer type

A McCaddon, G Davies, P Hudson… - … journal of geriatric …, 1998 - Wiley Online Library
Objective. The main hypothesis was that subtle vitamin B12 deficiencies occur more
commonly in senile dementia of Alzheimer type (SDAT) than in healthy elderly individuals …

Elevation of serum copper levels in Alzheimer's disease

R Squitti, D Lupoi, P Pasqualetti, G Dal Forno… - Neurology, 2002 - AAN Enterprises
Objective: To determine whether serum trace metals and oxidative species are related to
abnormal cognition in AD. Methods: The authors studied serum peroxides, copper, iron …

Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine

PI Ho, D Ashline, S Dhitavat, D Ortiz, SC Collins… - Neurobiology of …, 2003 - Elsevier
Clinical studies suggest a relationship between folate deficiency and neurological and
disorders including Alzheimer's disease (AD). To investigate mechanisms underlying this …

[HTML][HTML] Revisiting the role of vitamins and minerals in Alzheimer's disease

H Shah, F Dehghani, M Ramezan, RB Gannaban… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common type of dementia that affects millions of
individuals worldwide. It is an irreversible neurodegenerative disorder that is characterized …