Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation
The reaction of DNA-damaging agents with the genome results in a plethora of lesions,
commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent …
commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent …
Mouse behavioural analysis in systems biology
P Van Meer, J Raber - Biochemical Journal, 2005 - portlandpress.com
Molecular techniques allowing in vivo modulation of gene expression have provided unique
opportunities and challenges for behavioural studies aimed at understanding the function of …
opportunities and challenges for behavioural studies aimed at understanding the function of …
Direct, genome-wide assessment of DNA mutations in single cells
M Gundry, W Li, SB Maqbool, J Vijg - Nucleic acids research, 2012 - academic.oup.com
DNA mutations are the inevitable consequences of errors that arise during replication and
repair of DNA damage. Because of their random and infrequent occurrence, quantification …
repair of DNA damage. Because of their random and infrequent occurrence, quantification …
Influence of mus201 and mus308 mutations of Drosophila melanogaster on the genotoxicity of model chemicals in somatic cells in vivo measured with the comet …
C Bilbao, JA Ferreiro, MA Comendador… - … Molecular Mechanisms of …, 2002 - Elsevier
To check the possibilities of the recently developed comet assay, to be used in mechanistic
studies in Drosophila melanogaster, neuroblast cells of third instar larvae are used to …
studies in Drosophila melanogaster, neuroblast cells of third instar larvae are used to …
[HTML][HTML] Single-cell transcriptogenomics reveals transcriptional exclusion of ENU-mutated alleles
W Li, RB Calder, JC Mar, J Vijg - Mutation Research/Fundamental and …, 2015 - Elsevier
Recently, great progress has been made in single cell genomics and transcriptomics. Here,
we present an integrative method, termed single-cell transcriptogenomics (SCTG), in which …
we present an integrative method, termed single-cell transcriptogenomics (SCTG), in which …
N-ethyl-N-nitrosourea induces retinal photoreceptor damage in adult rats
K Yoshizawa, T Sasaki, N Uehara, M Kuro… - Journal of toxicologic …, 2012 - jstage.jst.go.jp
Seven-week-old male Lewis rats received a single intraperitoneal injection of N-ethyl-N-
nitrosourea (ENU)(100, 200, 400 or 600 mg/kg), and retinal damage was evaluated 7 days …
nitrosourea (ENU)(100, 200, 400 or 600 mg/kg), and retinal damage was evaluated 7 days …
Topoisomerase IIβ regulates base excision repair capacity of neurons
KP Gupta, U Swain, KS Rao, AK Kondapi - Mechanisms of ageing and …, 2012 - Elsevier
Topoisomerase IIβ (TopoIIβ), an enzyme involved in DNA rearrangements, is predominantly
present in brain and its levels are shown to decrease with age. This study characterizes the …
present in brain and its levels are shown to decrease with age. This study characterizes the …
Adaptive response to alkylating agents in the Drosophila sex-linked recessive lethal assay
N Savina, O Dalivelya, T Kuzhir - Mutation Research/Genetic Toxicology …, 2003 - Elsevier
The adaptive response to alkylating agents was studied in Drosophila assays under various
treatment procedures. Pre-treatment of males as well as treatment of females with low doses …
treatment procedures. Pre-treatment of males as well as treatment of females with low doses …
Female germ cell mutagenicity of model chemicals in Drosophila melanogaster: mechanistic information and analysis of repair systems
J Hernando, L Álvarez, JA Ferreiro, I Sancho… - Mutation Research …, 2004 - Elsevier
In spite of differences between female and male germ cells, and although both of them
contribute to the gene pool of future generations, most germ cell mutagenicity studies in …
contribute to the gene pool of future generations, most germ cell mutagenicity studies in …
Detected microsatellite polymorphisms in genetically altered inbred mouse strains
X Du, J Cui, C Wang, X Huo, J Lu, Y Li… - Molecular genetics and …, 2013 - Springer
Microsatellites are 50–200 repetitive DNA sequences composed of 1-to 6-base-pair-long
reiterative motifs within the genome. They are vulnerable to DNA modifications, such as …
reiterative motifs within the genome. They are vulnerable to DNA modifications, such as …