Background Successful chemoprevention or chemotherapy is achieved through targeted
delivery of prophylactic agents during initial phases of carcinogenesis or therapeutic agents …

Background Adjuvant 5-fluoruracil-based chemotherapy significantly decreases mortality
among patients with stage III colon cancer, but is less prescribed with rising age. We were …

Due to uncertainties regarding clinically meaningful gains from adjuvant chemotherapy after
colorectal cancer surgery, several Nordic Groups in the early 1990s initiated randomised …

Background In the UK, about 26% of patients diagnosed with colorectal cancer are classified
as Stage III (Dukes' C) at presentation. These patients have an overall 5-year survival rate of …

Background: Identifying various pretreatment factors that predict chemotherapy-induced
toxicity in colorectal cancer (CRC) patients undergoing treatment for their disease is crucial …

The majority of colorectal cancer patients receive chemotherapy either to palliate advanced
unresectable disease or to reduce the risk of recurrence after radical surgery. Thanks to the …

The normal colon epithelium is transformed into its neoplastic counterpart through a series
of genetic alterations in driver genes including activating mutations in PIK3CA. Treatment …

Chemotherapy remains a major treatment for malignant tumors, yet the application of
standard dose intensity chemotherapy is limited due to the side effects of cytotoxic drugs …

Background and aims There is considerable uncertainty as to whether adjuvant 5-
fluorouracil-based chemotherapy provides survival benefit for colon cancer patients with …

Objectives Feasible screening methods are important to identify older patients who might
benefit from adjuvant chemotherapy. The aim of this study was to investigate the …