[HTML][HTML] Bone remodeling: an operational process ensuring survival and bone mechanical competence

S Bolamperti, I Villa, A Rubinacci - Bone Research, 2022 - nature.com
Bone remodeling replaces old and damaged bone with new bone through a sequence of
cellular events occurring on the same surface without any change in bone shape. It was …

The bone remodelling cycle

JS Kenkre, JHD Bassett - Annals of clinical biochemistry, 2018 - journals.sagepub.com
The bone remodelling cycle replaces old and damaged bone and is a highly regulated,
lifelong process essential for preserving bone integrity and maintaining mineral …

[HTML][HTML] The effects of microgravity on bone structure and function

J Man, T Graham, G Squires-Donelly, AL Laslett - npj Microgravity, 2022 - nature.com
Humans are spending an increasing amount of time in space, where exposure to conditions
of microgravity causes 1–2% bone loss per month in astronauts. Through data collected …

[HTML][HTML] The role of matrix metalloproteinases in periodontal disease

V Checchi, T Maravic, P Bellini, L Generali… - International Journal of …, 2020 - mdpi.com
This review provides a detailed description of matrix metalloproteinases (MMPs), focusing
on those that are known to have critical roles in bone and periodontal disease. Periodontal …

Inflammatory bone loss: pathogenesis and therapeutic intervention

K Redlich, JS Smolen - Nature reviews Drug discovery, 2012 - nature.com
Bone is a tissue undergoing continuous building and degradation. This remodelling is a
tightly regulated process that can be disturbed by many factors, particularly hormonal …

Normal bone anatomy and physiology

B Clarke - Clinical journal of the American Society of Nephrology, 2008 - journals.lww.com
This review describes normal bone anatomy and physiology as an introduction to the
subsequent articles in this section that discuss clinical applications of iliac crest bone biopsy …

[HTML][HTML] Re-thinking the bone remodeling cycle mechanism and the origin of bone loss

JM Delaisse, TL Andersen, HB Kristensen, PR Jensen… - Bone, 2020 - Elsevier
Proper bone remodeling necessarily requires that osteoblasts reconstruct the bone that
osteoclasts have resorbed. However, the cellular events connecting resorption to …

Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis

SC Manolagas - Endocrine reviews, 2000 - academic.oup.com
The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

The elements of life and medicines

P Chellan, PJ Sadler - Philosophical Transactions of the …, 2015 - royalsocietypublishing.org
Which elements are essential for human life? Here we make an element-by-element journey
through the periodic table and attempt to assess whether elements are essential or not, and …

Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro

E Bonnelye, A Chabadel, F Saltel, P Jurdic - Bone, 2008 - Elsevier
Strontium ranelate is a newly developed drug that has been shown to significantly reduce
the risk of vertebral and non-vertebral fractures, including those of the hip, in …