The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …

It is widely accepted that the development of carcinoma—the most common form of human
cancer—is due to the accumulation of somatic mutations in epithelial cells. The behaviour of …

Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …

Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in
common certain structural characteristics, and most of whom bind heparin avidly. Many …

The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Aberrant activation of the androgen receptor (AR) may be one of the mechanisms which
contribute to progression of prostatic carcinoma to an androgen-independent stage. We …

Keratinocyte growth factor (KGF), also known as fibroblast growth factor 7 (FGF7), is
synthesized by skin fibroblasts. However, its mitogenic activity is on skin keratinocytes …

Cells possess within their epigenetic repertoire the ability to undergo an active process of
cellular suicide termed programmed (or apoptotic) cell death. This programmed cell death …

Prostatic development occurs as a result of an epithelial-mesenchymal interaction, which is
the basic developmental mechanism employed by all organs and organ systems composed …