Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR)
Gram-negative infections currently represents an unmet clinical need. Areas covered This …

Ventriculitis or post-neurosurgical meningitis or healthcare-associated ventriculitis and
meningitis (VM) is a severe infection that complicates central nervous system operations or …

Although available data are still limited, real-world evidence regarding mainly ceftolozane-
tazobactam and ceftazidime-avibactam could support the administration of novel beta …

Consolidated data from pharmacokinetic and pharmacodynamic studies support the
administration of β-lactam antibiotics in prolonged infusion (ie, extended or continuous) to …

Bacterial central nervous system (CNS) infections are serious and carry significant morbidity
and mortality. They encompass many syndromes, the most common being meningitis, which …

Clinicians should maintain a high index of suspicion for healthcare-associated central
nervous system infections in patients with specific risk factors (ie recent neurosurgery …

We report a case of multidrug-resistant Pseudomonas aeruginosa meningitis treated with
ceftolozane-tazobactam with concomitant therapeutic drug monitoring of plasma and …

Antimicrobial use in central nervous system infections : Current Opinion in Infectious Diseases
Antimicrobial use in central nervous system infections : Current Opinion in Infectious Diseases …

Several antibiotics with a low to moderate toxicity (in particular, β-lactam antibiotics,
fosfomycin, trimethoprim-sulfamethoxazole, rifampicin, vancomycin) can be administered at …

Nosocomial central nervous system (CNS) infections with carbapenem-and colistin-resistant
Gram-negative and vancomycin-resistant Gram-positive bacteria are an increasing …