The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …

Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in many processes, including DNA repair and cell death. The best known poly (ADP …

Poly-ADP-ribose metabolism plays a mayor role in a wide range of biological processes,
such as maintenance of genomic stability, transcriptional regulation, energy metabolism and …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a primary DNA damage sensor whose
(ADP-ribose) polymerase activity is acutely regulated by interaction with DNA breaks. Upon …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays a primary role in the process of poly (ADP-
ribosyl) ation. This posttranslational modification of nuclear proteins is activated in response …

Mammalian poly (ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear chromatin-
associated protein and belongs to a large family of enzymes that catalyzes the transfer of …

Poly (ADP-ribosyl) ation is an important mechanism for the maintenance of genomic integrity
in response to DNA damage. The enzyme responsible for poly (ADP-ribose) synthesis, poly …

One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post‐
translational modification of nuclear proteins with poly (ADP‐ribose) from NAD+ as …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a chromatin-associated enzyme with multiple
cellular functions, including DNA repair, transcriptional regulation, and cell signaling. PARP …