Coordination of DNA single strand break repair
R Abbotts, DM Wilson III - Free Radical Biology and Medicine, 2017 - Elsevier
The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …
changes are programmed, such as the formation of DNA double strand breaks during …
The therapeutic potential of poly (ADP-ribose) polymerase inhibitors
Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …
Poly (ADP-ribose) polymerase-1 cleavage during apoptosis: an update
C Soldani, AI Scovassi - Apoptosis, 2002 - Springer
Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in many processes, including DNA repair and cell death. The best known poly (ADP …
in many processes, including DNA repair and cell death. The best known poly (ADP …
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases
PO Hassa, MO Hottiger - Frontiers in Bioscience (Landmark Edition), 2008 - zora.uzh.ch
Poly-ADP-ribose metabolism plays a mayor role in a wide range of biological processes,
such as maintenance of genomic stability, transcriptional regulation, energy metabolism and …
such as maintenance of genomic stability, transcriptional regulation, energy metabolism and …
The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks
AAE Ali, G Timinszky, R Arribas-Bosacoma… - Nature structural & …, 2012 - nature.com
Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a primary DNA damage sensor whose
(ADP-ribose) polymerase activity is acutely regulated by interaction with DNA breaks. Upon …
(ADP-ribose) polymerase activity is acutely regulated by interaction with DNA breaks. Upon …
[HTML][HTML] PARP-1, a determinant of cell survival in response to DNA damage
VJ Bouchard, M Rouleau, GG Poirier - Experimental hematology, 2003 - Elsevier
Poly (ADP-ribose) polymerase-1 (PARP-1) plays a primary role in the process of poly (ADP-
ribosyl) ation. This posttranslational modification of nuclear proteins is activated in response …
ribosyl) ation. This posttranslational modification of nuclear proteins is activated in response …
The functional role of poly (ADP-ribose) polymerase 1 as novel coactivator of NF-κB in inflammatory disorders
PO Hassa, MO Hottiger - Cellular and Molecular Life Sciences CMLS, 2002 - Springer
Mammalian poly (ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear chromatin-
associated protein and belongs to a large family of enzymes that catalyzes the transfer of …
associated protein and belongs to a large family of enzymes that catalyzes the transfer of …
Gain-of-function of poly (ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis
D D'Amours, FR Sallmann, VM Dixit… - Journal of cell …, 2001 - journals.biologists.com
Poly (ADP-ribosyl) ation is an important mechanism for the maintenance of genomic integrity
in response to DNA damage. The enzyme responsible for poly (ADP-ribose) synthesis, poly …
in response to DNA damage. The enzyme responsible for poly (ADP-ribose) synthesis, poly …
Physiology and pathophysiology of poly (ADP‐ribosyl) ation
A Bürkle - Bioessays, 2001 - Wiley Online Library
One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post‐
translational modification of nuclear proteins with poly (ADP‐ribose) from NAD+ as …
translational modification of nuclear proteins with poly (ADP‐ribose) from NAD+ as …
A third zinc-binding domain of human poly (ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation
MF Langelier, KM Servent, EE Rogers… - Journal of biological …, 2008 - ASBMB
Poly (ADP-ribose) polymerase-1 (PARP-1) is a chromatin-associated enzyme with multiple
cellular functions, including DNA repair, transcriptional regulation, and cell signaling. PARP …
cellular functions, including DNA repair, transcriptional regulation, and cell signaling. PARP …