From strings to signals: Unraveling the impact of miRNAs on diagnosis, and progression of colorectal cancer

OA Mohammed - Pathology-Research and Practice, 2023 - Elsevier
Colorectal cancer (CRC) stands as the third most prevalent ailment globally and represents
the primary cause of mortality associated with cancer. Significant advancements have been …

The potential relevance of long non-coding RNAs in colorectal cancer pathogenesis and treatment: A review focus on signaling pathways

AS Doghish, MB Zaki, MG Eldeib, AF Radwan… - … -Research and Practice, 2023 - Elsevier
Colorectal cancer (CRC) is one of the most frequent cancers in incidence and mortality.
Despite advances in cancer biology, molecular genetics, and targeted treatments, CRC …

Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: Novel insights on autophagy, apoptosis, and pyroptosis

R Abdelhady, S Saber… - Frontiers in …, 2023 - frontiersin.org
Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal area that
demonstrates a dramatically increasing incidence worldwide. This study provides novel …

Alvespimycin exhibits potential anti-TGF-β signaling in the setting of a proteasome activator in rats with bleomycin-induced pulmonary fibrosis: a promising novel …

OA Mohammed, MA Abdel-Reheim, LA Saleh… - Pharmaceuticals, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an irreversible and life-threatening lung disease of
unknown etiology presenting only a few treatment options. TGF-β signaling orchestrates a …

[HTML][HTML] Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling

S Saber, EE Abd El-Fattah, AM Abdelhamid… - Biomedicine & …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third foremost cause of cancer-related deaths. HCC
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …

Itraconazole halts hepatocellular carcinoma progression by modulating sonic hedgehog signaling in rats: A novel therapeutic approach

OA Mohammed, AS Doghish, LA Saleh… - … -Research and Practice, 2024 - Elsevier
Liver cancer stands as the fourth leading global cause of death, and its prognosis remains
grim due to the limited effectiveness of current medical interventions. Among the various …

[HTML][HTML] Diacetylrhein, an anthraquinone antiarthritic agent, suppresses dextran sodium sulfate-induced inflammation in rats: A possible mechanism for a protective …

MH Zohny, M Alrouji, S Alhajlah, O AlOmeir… - Biomedicine & …, 2022 - Elsevier
Ulcerative colitis (UC) is a chronic inflammatory life-threatening and premalignant disorder
with no cure that even might end up with surgical removal of a large section or even all of the …

Oxysophocarpine suppresses TRAF6 level to ameliorate oxidative stress and inflammatory factors secretion in mice with dextran sulphate sodium (DSS) induced …

C Liu, R Wang, X Jiao, J Zhang, C Zhang… - Microbial Pathogenesis, 2023 - Elsevier
Purpose Ulcerative colitis is an inflammation-related disease with a high recurrence risk.
Oxysophocarpine (OSC) is a traditional Chinese medicine isolated from legumes and exerts …

The role of organosulfur compounds as Nrf2 activators and their antioxidant effects

MC Egbujor, M Petrosino, K Zuhra, L Saso - Antioxidants, 2022 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling has become a key pathway for
cellular regulation against oxidative stress and inflammation, and therefore an attractive …

Alogliptin exhibits multifaceted effects in thioacetamide-insulted rats: a novel approach to combating hepatic inflammation and fibrogenesis

OA Mohammed - Pathology-Research and Practice, 2023 - Elsevier
Hepatic fibrosis arising from chronic liver injury is characterized by dysregulated healing,
including hepatic stellate cell activation and excessive deposition of extracellular matrix …