Cancer/testis antigens: from serology to mRNA cancer vaccine

C Fan, H Qu, X Wang, N Sobhani, L Wang, S Liu… - Seminars in cancer …, 2021 - Elsevier
Cancer/testis antigens (CTAs) are a group of tumor antigens expressed in numerous cancer
tissues, as well as in the testis and placental tissues. There are over 200 CTAs supported by …

Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine

S Ren, Z Zhang, M Li, D Wang… - International …, 2023 - spandidos-publications.com
Cancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis
and treatment. Most CTAs are located on the X chromosome and aggregate into large gene …

Anti-cancer auto-antibodies: Roles, applications and open issues

H de Jonge, L Iamele, M Maggi, G Pessino, C Scotti - Cancers, 2021 - mdpi.com
Simple Summary Cancer is one of the main causes of death worldwide and early detection
is crucial for effective treatment. Scientists have therefore focused on the identification of …

The paradox of cancer genes in non-malignant conditions: implications for precision medicine

JJ Adashek, S Kato, SM Lippman, R Kurzrock - Genome medicine, 2020 - Springer
Next-generation sequencing has enabled patient selection for targeted drugs, some of
which have shown remarkable efficacy in cancers that have the cognate molecular …

[HTML][HTML] Sperm proteins and cancer‐testis antigens are released by the seminiferous tubules in mice and men

L O'Donnell, D Rebourcet, LF Dagley, R Sgaier… - The FASEB …, 2021 - ncbi.nlm.nih.gov
Sperm develop from puberty in the seminiferous tubules, inside the blood‐testis barrier to
prevent their recognition as “non‐self” by the immune system, and it is widely assumed that …

Development of autoantibody signatures for common cancers

M Kobayashi, H Katayama, JF Fahrmann… - Seminars in …, 2020 - Elsevier
A humoral immune response in the form of autoantibodies to tumor antigens occurs early
during tumor development. Identification of antigens that induce an autoantibody response …

Discovering panel of autoantibodies for early detection of lung cancer based on focused protein array

D Jiang, X Zhang, M Liu, Y Wang, T Wang… - Frontiers in …, 2021 - frontiersin.org
Substantial studies indicate that autoantibodies to tumor-associated antigens (TAAbs) arise
in early stage of lung cancer (LC). However, since single TAAbs as non-invasive biomarkers …

Comprehensive analysis of the carcinogenic process, tumor microenvironment, and drug response in HPV-positive cancers

X Yu, J Xu, D Xu, X Bi, H Wang, Y Lu, M Cao… - Frontiers in …, 2022 - frontiersin.org
Human papillomavirus (HPV) is a common virus, and about 5% of all cancers worldwide is
caused by persistent high-risk HPV infections. Here, we reported a comprehensive analysis …

The diagnostic efficiency of seven autoantibodies in lung cancer

H Huang, W Luo, Y Ni, S Sun, C Wang… - European Journal of …, 2020 - journals.lww.com
This study aimed to evaluate the diagnostic efficacy of seven autoantibodies in all lung
cancer, lung adenocarcinoma, lung squamous cell carcinoma and early-stage lung cancer …

Identification of novel autoantibodies based on the human proteomic chips and evaluation of their performance in the detection of gastric cancer

C Cui, Y Duan, C Qiu, P Wang, G Sun, H Ye… - Frontiers in …, 2021 - frontiersin.org
Autoantibodies against tumor-associated antigens (TAAbs) can be used as potential
biomarkers in the detection of cancer. Our study aims to identify novel TAAbs for gastric …