Molecular mechanisms of transgenerational epigenetic inheritance
MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …
inherited across several generations in organisms ranging from yeast to plants to humans …
Environmental factors in declining human fertility
NE Skakkebæk, R Lindahl-Jacobsen… - Nature Reviews …, 2022 - nature.com
A severe decline in child births has occurred over the past half century, which will lead to
considerable population declines, particularly in industrialized regions. A crucial question is …
considerable population declines, particularly in industrialized regions. A crucial question is …
Exploring the expanding universe of small RNAs
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …
Advances in epigenetics link genetics to the environment and disease
Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
RNA modifications modulate gene expression during development
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programs. They affect diverse eukaryotic biological processes, and the correct …
expression programs. They affect diverse eukaryotic biological processes, and the correct …
Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment
E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …
associated with a substantially increased lifetime risk of comorbidities, including type 2 …
Origins of lifetime health around the time of conception: causes and consequences
Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …
affect the health and chronic disease risk of people throughout their lives, as captured in the …
Intergenerational and transgenerational epigenetic inheritance in animals
Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …
metabolites, to their progeny via gametes. It is currently unclear to what extent these …
Animal models of obesity and diabetes mellitus
More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …