Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …

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Initiation of cyst formation in autosomal dominant polycystic kidney disease (ADPKD) occurs
when kidney tubule cells are rendered null for either PKD1 or PKD2 by somatic 'second …

While deforestation rates decline globally they are rising in the Western Amazon. Artisanal-
scale gold mining (ASGM) is a large cause of this deforestation and brings with it extensive …

Polycystic kidney disease (PKD) is a life-threatening disorder, commonly caused by defects
in polycystin-1 (PC1) or polycystin-2 (PC2), in which tubular epithelia form fluid-filled cysts …

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal,
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …

Kidney cysts occur following inactivation of polycystins in otherwise intact cilia or following
complete removal of cilia by inactivation of intraflagellar transport–related proteins. We …

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal
monogenic disorder. It has large inter-and intra-familial variability explained to a large extent …

Respect for the primary cilium has undergone a remarkable renaissance over the past
decade, and it is now thought to be an essential regulator of numerous signaling pathways …

The mTOR pathway is the central regulator of cell size. External signals from growth factors
and nutrients converge on the mTORC1 multi-protein complex to modulate downstream …