Structural organization of the retriever–CCC endosomal recycling complex
The recycling of membrane proteins from endosomes to the cell surface is vital for cell
signaling and survival. Retriever, a trimeric complex of vacuolar protein-sorting-associated …
signaling and survival. Retriever, a trimeric complex of vacuolar protein-sorting-associated …
Chemoattractant receptor signaling in humoral immunity
T Shirai, A Nakai, K Suzuki - International Immunology, 2024 - academic.oup.com
Efficient induction of humoral immune responses depends on orchestrated migration of B
cells within lymphoid organs, which is governed by G protein-coupled receptors (GPCRs) …
cells within lymphoid organs, which is governed by G protein-coupled receptors (GPCRs) …
Potential mechanisms of rheumatoid arthritis therapy: Focus on macrophage polarization
X Yang, J Li, C Xu, G Zhang, X Che, J Yang - International …, 2024 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that affects multiple
organs and systems in the human body, often leading to disability. Its pathogenesis is …
organs and systems in the human body, often leading to disability. Its pathogenesis is …
Celastrol alleviates airway hyperresponsiveness and inflammation in obese asthma through mediation of alveolar macrophage polarization
Y Liang, S Shen, X Ye, W Zhang, X Lin - European Journal of …, 2024 - Elsevier
Obese asthma is a unique asthma phenotype that decreases sensitivity to inhaled
corticosteroids, and currently lacks efficient therapeutic medication. Celastrol, a powerful …
corticosteroids, and currently lacks efficient therapeutic medication. Celastrol, a powerful …
Celastrol alleviates diabetic vascular injury via Keap1/Nrf2-mediated anti-inflammation
N An, R Wang, L Li, B Wang, H Wang… - Frontiers in …, 2024 - frontiersin.org
Introduction: Celastrol (Cel) is a widely used main component of Chinese herbal medicine
with strong anti-inflammatory, antiviral and antitumor activities. In the present study, we …
with strong anti-inflammatory, antiviral and antitumor activities. In the present study, we …
Identification of Hedyotisdiffusa Willd-specific mRNA–miRNA–lncRNA network in rheumatoid arthritis based on network pharmacology, bioinformatics analysis, and …
J Jiang, M Huang, SS Zhang, YG Wu, XL Li, H Deng… - Scientific Reports, 2024 - nature.com
Hedyotis diffusa Willd (HDW) possesses heat-clearing, detoxification, anti-cancer, and anti-
inflammatory properties. However, its effects on rheumatoid arthritis (RA) remain under …
inflammatory properties. However, its effects on rheumatoid arthritis (RA) remain under …
Bergenin attenuates triptolide-caused premature ovarian failure in mice based on the antioxidant activity
Y Zhu, L Yao, Y Guo, J Zhang, Y Xia, Z Wei… - Reproductive Toxicology, 2024 - Elsevier
Tripterygium wilfordii (TW) preparations have been utilized in China for treating rheumatoid
arthritis and autoimmune diseases. However, their clinical use is limited due to reproductive …
arthritis and autoimmune diseases. However, their clinical use is limited due to reproductive …
Dissection of Targeting Molecular Mechanisms of Celastrol-induced Nephrotoxicity via A Combined Deconvolution Strategy of Chemoproteomics and Metabolomics
X Liu, Q Zhang, P Wang, X Peng, Y An, J Chen… - International Journal of …, 2024 - ijbs.com
Celastrol (Cel), derived from the traditional herb Tripterygium wilfordii Hook. f., has anti-
inflammatory, anti-tumor, and immunoregulatory activities. Renal dysfunction, including …
inflammatory, anti-tumor, and immunoregulatory activities. Renal dysfunction, including …
[HTML][HTML] Demethylzeylasteral exerts potent efficacy against non-small-cell lung cancer via the P53 signaling pathway
L Lv, F Zhou, Y Quan, Y Fan, Y Bao, Y Dou, H Qu… - Translational …, 2024 - Elsevier
Lung cancer has one of the highest mortality rates worldwide, with non-small-cell lung
cancer (NSCLC) constituting approximately 85% of all cases. Demethylzeylasteral (DEM) …
cancer (NSCLC) constituting approximately 85% of all cases. Demethylzeylasteral (DEM) …
PTEN status determines therapeutic vulnerability to celastrol in cholangiocarcinoma
YF Pan, L Zhong, M Wang, TY Jiang, Y Lin, YB Chen… - Phytomedicine, 2024 - Elsevier
Background A balanced protein homeostasis network helps cholangiocarcinoma (CCA)
maintain their oncogenic growth, and disrupting proteostasis therapeutically will induce …
maintain their oncogenic growth, and disrupting proteostasis therapeutically will induce …