[HTML][HTML] The endosomal recycling pathway—at the crossroads of the cell
MJ O'sullivan, AJ Lindsay - International journal of molecular sciences, 2020 - mdpi.com
The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in
the cell. It plays a central role in determining the composition of the plasma membrane and …
the cell. It plays a central role in determining the composition of the plasma membrane and …
Overcoming trastuzumab resistance in HER2‐positive breast cancer using combination therapy
A Derakhshani, Z Rezaei, H Safarpour… - Journal of cellular …, 2020 - Wiley Online Library
Human epidermal growth factor receptor 2 (HER2)‐positive breast cancer (BC) comprises
around 20–30% of all BC subtypes and is correlated with poor prognosis. For many years …
around 20–30% of all BC subtypes and is correlated with poor prognosis. For many years …
Control of cell state transitions
Understanding cell state transitions and purposefully controlling them is a longstanding
challenge in biology. Here we present cell state transition assessment and regulation …
challenge in biology. Here we present cell state transition assessment and regulation …
[HTML][HTML] Cell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis
D Paul, O Stern, Y Vallis, J Dhillon, A Buchanan… - Nature …, 2023 - nature.com
The ability of cells to manage consequences of exogenous proteotoxicity is key to cellular
homeostasis. While a plethora of well-characterised machinery aids intracellular …
homeostasis. While a plethora of well-characterised machinery aids intracellular …
Radioimmunotherapy of cancer with high linear energy transfer (LET) radiation delivered by radionuclides emitting α-particles or Auger electrons
Radioimmunotherapy (RIT) aims to selectively deliver radionuclides emitting α-particles, β-
particles or Auger electrons to tumors by conjugation to monoclonal antibodies (mAbs) that …
particles or Auger electrons to tumors by conjugation to monoclonal antibodies (mAbs) that …
Relative target affinities of T-cell–dependent bispecific antibodies determine biodistribution in a solid tumor mouse model
D Mandikian, N Takahashi, AA Lo, J Li… - Molecular cancer …, 2018 - AACR
Abstract Anti-HER2/CD3, a T-cell–dependent bispecific antibody (TDB) construct, induces T-
cell–mediated cell death in cancer cells expressing HER2 by cross-linking tumor HER2 with …
cell–mediated cell death in cancer cells expressing HER2 by cross-linking tumor HER2 with …
[HTML][HTML] Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
Human epidermal growth factor receptor 2 (HER2) gene amplification and/or protein
overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although …
overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although …
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling
B Wilding, D Scharn, D Boese, A Baum, V Santoro… - Nature Cancer, 2022 - nature.com
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in
approximately 2% of patients with non-small cell lung cancer and predominantly affect the …
approximately 2% of patients with non-small cell lung cancer and predominantly affect the …
[HTML][HTML] Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes
A major unmet clinical need is a universal method for subcellular targeting of bioactive
molecules to lysosomes. Delivery to this organelle enables either degradation of oncogenic …
molecules to lysosomes. Delivery to this organelle enables either degradation of oncogenic …
Quantitative study of the interaction of multivalent ligand-modified nanoparticles with breast cancer cells with tunable receptor density
Multivalent nanoparticles that target a cell surface receptor that is overexpressed by cancer
cells are a promising delivery system for cancer therapy. However, the impact of the receptor …
cells are a promising delivery system for cancer therapy. However, the impact of the receptor …