Abstract Although anti–HLA (Human Leukocyte Antigen) donor-specific antibodies (DSAs)
are commonly measured in clinical practice and their relationship with transplant outcome is …

Organ transplantation has progressed with the comprehension of the major
histocompatibility complex (MHC). It is true that the outcome of organ transplantation largely …

Islet transplantation represents an effective treatment for patients with type 1 diabetes
mellitus (T1DM) and severe hypoglycaemia unawareness, capable of circumventing …

Lung transplantation is the optimal treatment for selected patients with end-stage chronic
lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to …

Factors contributing to donor-specific HLA antibody (DSA) development after lung
transplantation have not been systematically evaluated. We hypothesized that the isolation …

Fc gamma receptors (FcγRs) play a major role in the regulation of humoral immune
responses. Single-nucleotide polymorphisms (SNPs) of FCGR2A and FCGR3A can impact …

BACKGROUND Chronic lung allograft dysfunction (CLAD) is the major complication limiting
long-term survival in lung transplant recipients (LTRs), with those developing donor-specific …

Transplantation is a treatment option for patients diagnosed with end-stage organ diseases;
however, long-term graft survival is affected by rejection of the transplanted organ by …

Lung transplant recipients (LTxRs) with acute or chronic rejection release circulating
exosomes that mostly originate from donor lung tissue and express mismatched human …

Background. Data supporting the use of carfilzomib (CFZ) for treatment of antibody-mediated
rejection (AMR) in lung transplantation in combination with plasmapheresis and intravenous …