Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development
and plasticity in both health and disease. Recent studies using mutant mice to selectively …

Melatonin, N-acetyl-5-hydroxytryptamine, is a hormone that synchronizes the internal
environment with the photoperiod. It is synthesized in the pineal gland and greatly depends …

Many therapies with potential for treatment of brain injury have been investigated. Few types
of cells have spurred as much interest and excitement as stem cells over the past few …

Abstract Cannabinoid CB1 receptors (CB 1 R) and serotonergic 2A receptors (5HT 2A R)
form heteromers in the brain of mice where they mediate the cognitive deficits produced by …

Response to antidepressants is related to hippocampal neurogenesis integrity, a process
mediated by neurotrophins, such as Brain Derived Neurotrophic Factor (BDNF). In turn, pro …

Inflammation contributes to neonatal brain injury. Pro-inflammatory cytokines represent key
inflammatory meditators in neonatal hypoxic-ischemic (HI) brain injury. The high mobility …

Poorly differentiated sinonasal carcinomas (PDCs) are tumors that have a poor prognosis
despite advances in classical treatment. Predictive and prognostic markers and new …

Abstract Treatment of stroke remains difficult due to the unsatisfactory or unlocalized delivery
of small molecule-and cell-based therapeutics in injured brain tissues. This is particularly the …

Schizophrenia (SCZ) has been associated with serotonergic and endocannabinoid systems
dysregulation, but difficulty in obtaining in vivo neurological tissue has limited its exploration …

Background Discovering biological markers is essential for understanding and treating
mental disorders. Despite the limitations of current non-invasive methods, neural progenitor …