A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Proteins are the most abundant biomolecules within a cell and are involved in all
biochemical cellular processes, fulfilling specific functions with unmatched precision. This …

Bioconjugation chemistry has been used to prepare modified biomolecules with functions
beyond what nature intended. Central to these techniques is the development of highly …

Cyclic peptides are among the most diverse architectures for current drug discovery efforts.
Their size, stability, and ease of synthesis provide attractive scaffolds to engage and …

Macrocyclic peptides (MPs) have positioned themselves as a privileged class of compounds
for the discovery of therapeutics and development of chemical probes. Aided by the …

Genetically encoded macrocyclic peptide libraries with unnatural pharmacophores are
valuable sources for the discovery of ligands for many targets of interest. Traditionally …

Macrocyclic peptides are promising scaffolds for the covalent ligand discovery. However,
platforms enabling the direct identification of covalent macrocyclic ligands in a high …

Ribosomally expressed proteins perform multiple, versatile, and specialized tasks
throughout Nature. In modern times, chemically modified proteins, including improved …

A new method for cysteine–lysine cross-linking in peptides and proteins using palladium
oxidative addition complexes is presented. First, a biarylphosphine-supported palladium …