Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
Forty years of clathrin‐coated vesicles
MS Robinson - Traffic, 2015 - Wiley Online Library
The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …
Genetic and molecular architecture of familial hypercholesterolemia
M Abifadel, C Boileau - Journal of internal medicine, 2023 - Wiley Online Library
Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its
important risk of premature atherosclerosis and cardiovascular disease, familial …
important risk of premature atherosclerosis and cardiovascular disease, familial …
The mechanisms of vesicle budding and fusion
JS Bonifacino, BS Glick - cell, 2004 - cell.com
Genetic and biochemical analyses of the secretory pathway have produced a detailed
picture of the molecular mechanisms involved in selective cargo transport between …
picture of the molecular mechanisms involved in selective cargo transport between …
Endocytosis in the context-dependent regulation of individual and collective cell properties
S Sigismund, L Lanzetti, G Scita… - Nature Reviews Molecular …, 2021 - nature.com
Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …
In addition, it is involved in the termination of signalling through receptor downmodulation …
[HTML][HTML] Monogenic hypercholesterolemia: new insights in pathogenesis and treatment
DJ Rader, J Cohen, HH Hobbs - The Journal of clinical …, 2003 - Am Soc Clin Investig
The careful clinical characterization of patients with genetic forms of severe
hypercholesterolemia has played a critical role in the historic linkage of …
hypercholesterolemia has played a critical role in the historic linkage of …
Adaptable adaptors for coated vesicles
MS Robinson - Trends in cell biology, 2004 - cell.com
Adaptors select cargo for inclusion into coated vesicles in the late secretory and endocytic
pathways. Although originally there were thought to be just two adaptors, AP-1 and AP-2, it …
pathways. Although originally there were thought to be just two adaptors, AP-1 and AP-2, it …
Clathrin-mediated endocytosis in AP-2–depleted cells
A Motley, NA Bright, MNJ Seaman… - The Journal of cell …, 2003 - rupress.org
We have used RNA interference to knock down the AP-2 μ2 subunit and clathrin heavy
chain to undetectable levels in HeLaM cells. Clathrin-coated pits associated with the plasma …
chain to undetectable levels in HeLaM cells. Clathrin-coated pits associated with the plasma …
Adaptors for clathrin coats: structure and function
DJ Owen, BM Collins, PR Evans - Annu. Rev. Cell Dev. Biol., 2004 - annualreviews.org
▪ Abstract Clathrin-coated vesicles (CCVs) are responsible for the transport of proteins
between various compartments of the secretory and endocytic systems. Clathrin forms a …
between various compartments of the secretory and endocytic systems. Clathrin forms a …
Structure and physiologic function of the low-density lipoprotein receptor
H Jeon, SC Blacklow - Annu. Rev. Biochem., 2005 - annualreviews.org
▪ Abstract The low-density lipoprotein receptor (LDLR) is responsible for uptake of
cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at …
cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at …