Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its
important risk of premature atherosclerosis and cardiovascular disease, familial …

Genetic and biochemical analyses of the secretory pathway have produced a detailed
picture of the molecular mechanisms involved in selective cargo transport between …

Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …

The careful clinical characterization of patients with genetic forms of severe
hypercholesterolemia has played a critical role in the historic linkage of …

Adaptors select cargo for inclusion into coated vesicles in the late secretory and endocytic
pathways. Although originally there were thought to be just two adaptors, AP-1 and AP-2, it …

We have used RNA interference to knock down the AP-2 μ2 subunit and clathrin heavy
chain to undetectable levels in HeLaM cells. Clathrin-coated pits associated with the plasma …

▪ Abstract Clathrin-coated vesicles (CCVs) are responsible for the transport of proteins
between various compartments of the secretory and endocytic systems. Clathrin forms a …

▪ Abstract The low-density lipoprotein receptor (LDLR) is responsible for uptake of
cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at …