Healthy cells use autophagy as a general'housekeeping'mechanism and to survive stress,
including stress induced by nutrient deprivation. Autophagy is initiated at the isolation …

Autophagy is a cellular process that targets proteins, lipids and organelles to lysosomes for
degradation, but it has also been shown to combat infection with various pathogenic …

Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic
components, including cytosol and organelles, to the lysosome in double-membrane …

Bilayered phospholipid membranes are vital to the organization of the living cell. Based on
fundamental principles of polarity, membranes create borders allowing defined spaces to be …

Macroautophagy requires membrane trafficking and remodelling to form the
autophagosome and deliver its contents to lysosomes for degradation. We have previously …

Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular
functions throughout all phases of the cell cycle. Altered tubulin isotype composition of …

Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic
materials, involves double-membrane autophagosomes formed when an isolation …

Understanding organelle biogenesis is a central focus of cell biology. Whereas some are
generated from existing organelles, others can be generated de novo. Most de novo …

Multiple sources contribute membrane and protein machineries to construct functional
macroautophagic/autophagic structures. However, the underlying molecular mechanisms …