Following the discovery of HIV as a causative agent of AIDS, the expectation was to rapidly
develop a vaccine; but thirty years later, we still do not have a licensed vaccine. Progress …

Ligation of the inhibitory receptor NKG2A by its ligand HLA-E negatively regulates the
activation of natural killer (NK) cells, as well as subsets of CD8+ T cells and innate T cell …

Multiple studies have broadened the roles of natural killer (NK) cells functioning as purely
innate lymphocytes by demonstrating that they are capable of putative antigen-specific …

Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …

Peptides presented by HLA-E, a molecule with very limited polymorphism, represent
attractive targets for T cell receptor (TCR)-based immunotherapies to circumvent the …

Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a
natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of …

Abstract Histocompatibility Leukocyte Antigens, or HLAs, are one of the most polymorphic
molecules in humans. This high degree of polymorphism endows HLA molecules with the …

The essentially monomorphic human antigen presentation molecule HLA-E is an interesting
candidate target to enable vaccination irrespective of genetic diversity. Predictive HLA-E …

Advances in immunotherapy rely on targeting novel cell surface antigens, including
therapeutically relevant peptide fragments presented by HLA molecules, collectively known …

CD8+ T cell responses restricted by MHC-E, a nonclassical MHC molecule, have been
associated with protection in an SIV/rhesus macaque model. The biological relevance of …