Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Background Despite a variety of pharmacological and device therapies for persons with
chronic heart failure (HF), prognosis and quality of life (QOL) remain poor. The need for new …

The world population is aging and the number of old people is continuously increasing.
Arterial structure and function change with age, progressively leading to arterial stiffening …

Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive
dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen …

Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM)
proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging …

There is a close relationship between arterial stiffness and blood pressure. The studies
suggest that the advanced glycation end products (AGEs) and its cell receptor (RAGE) are …

Advanced glycation end products (AGEs) are a family of compounds of diverse chemical
nature that are the products of nonenzymatic reactions between reducing sugars and …

Arterial stiffness has been recognized as a marker of cardiovascular disease and associated
with long-term worse clinical outcomes in several populations. Age, hypertension, smoking …

Human ageing is determined by degenerative alterations and processes with different
manifestations such as gradual organ dysfunction, tissue function loss, increased population …

Aortic stiffening is a major independent risk factor for cardiovascular diseases, kidney
dysfunction, and cognitive impairment. Doxorubicin chemotherapy-treated cancer survivors …