Abstract Interleukin (IL)-6 is a pro-inflammatory cytokine that is expressed in prostate tumors
and in the stromal tumor micro-enviroment. It is known to regulate proliferation, apoptosis …

As a member of the suppressor of cytokine signaling (SOCS) family, SOCS3 is a cytokine-
inducible protein that inhibits cytokine signaling in a variety of signaling pathways …

Skeletal muscle excitation–contraction (EC) coupling is initiated by sarcolemmal
depolarization, which is translated into a conformational change of the dihydropyridine …

Androgen deprivation therapy (ADT) is a cornerstone treatment for locally advanced or
metastatic prostate cancer (PCa). However, its potential effects on the tumor immune …

Enzalutamide, an antiandrogen, is approved for therapy of castration resistant prostate
cancer. Clinical applications have shown that approximately 30% of patients acquire …

Glioblastoma multiforme (GBM) is a poor prognosis type of tumour due to its resistance to
chemo and radiotherapy. SOCS1 and SOCS3 have been associated with tumour …

Abstract Purpose of Review Compensatory mechanisms leading to increased androgen
receptor expression and activity after androgen ablation or anti-androgen treatment have …

Enzalutamide, a second-generation small-molecule inhibitor of the androgen receptor (AR),
has been approved for patients who failed with androgen deprivation therapy and have …

Simple Summary Prostate cancer (PCa) is the second most common cancer in men and one
of the leading causes of death. Signal transducers and activators of transcription (STATs) …

Prostate cancer (PC) is the most frequently diagnosed cancer and the second leading cause
of cancer-related death in men in the Western society. Unfortunately, although the vast …