Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

Autophagy-dependent cell death can be defined as cell demise that has a strict requirement
of autophagy. Although autophagy often accompanies cell death following many toxic …

Post-translational modifications, such as phosphorylation, ubiquitination and acetylation,
play crucial roles in the regulation of autophagy. Acetylation has emerged as an important …

Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Immunotherapies targeting the PD-1/PD-L1 axis have become first-line treatments in
multiple cancers. However, only a limited subset of individuals achieves durable benefits …

Life and health span can be prolonged by calorie limitation or by pharmacologic agents that
mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient …

Autophagy is essential for cellular survival and energy homeostasis under nutrient
deprivation. Despite the emerging importance of nuclear events in autophagy regulation …

Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …