Cryptosporidium pathogenicity and virulence
M Bouzid, PR Hunter, RM Chalmers… - Clinical microbiology …, 2013 - Am Soc Microbiol
Cryptosporidium is a protozoan parasite of medical and veterinary importance that causes
gastroenteritis in a variety of vertebrate hosts. Several studies have reported different …
gastroenteritis in a variety of vertebrate hosts. Several studies have reported different …
[HTML][HTML] Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites
JR Haanstra, EB González-Marcano… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Peroxisomes of organisms belonging to the protist group Kinetoplastea, which include
trypanosomatid parasites of the genera Trypanosoma and Leishmania, are unique in …
trypanosomatid parasites of the genera Trypanosoma and Leishmania, are unique in …
[HTML][HTML] The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes
P Capewell, C Cren-Travaillé, F Marchesi, P Johnston… - Elife, 2016 - elifesciences.org
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan
parasites has been overlooked for decades as these pathogens have been regarded …
parasites has been overlooked for decades as these pathogens have been regarded …
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome
S Alsford, DJ Turner, SO Obado… - Genome …, 2011 - genome.cshlp.org
African trypanosomes are major pathogens of humans and livestock and represent a model
for studies of unusual protozoal biology. We describe a high-throughput phenotyping …
for studies of unusual protozoal biology. We describe a high-throughput phenotyping …
Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei
The protozoan parasites Trypanosoma brucei spp. cause important human and livestock
diseases in sub-Saharan Africa. In mammalian blood, two developmental forms of the …
diseases in sub-Saharan Africa. In mammalian blood, two developmental forms of the …
[HTML][HTML] Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen
The African trypanosome, Trypanosoma brucei, maintains an integral link between cell cycle
regulation and differentiation during its intricate life cycle. Whilst extensive changes in …
regulation and differentiation during its intricate life cycle. Whilst extensive changes in …
[HTML][HTML] Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing
Developmental steps in the trypanosome life-cycle involve transition between replicative
and non-replicative forms specialised for survival in, and transmission between, mammalian …
and non-replicative forms specialised for survival in, and transmission between, mammalian …
[HTML][HTML] Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection
JF Quintana, P Chandrasegaran, MC Sinton… - Nature …, 2022 - nature.com
Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasite
Trypanosoma brucei and induces profound reactivity of glial cells and neuroinflammation …
Trypanosoma brucei and induces profound reactivity of glial cells and neuroinflammation …
[HTML][HTML] Oligopeptide signaling through TbGPR89 drives trypanosome quorum sensing
F Rojas, E Silvester, J Young, R Milne, M Tettey… - Cell, 2019 - cell.com
Trypanosome parasites control their virulence and spread by using quorum sensing (QS) to
generate transmissible" stumpy forms" in their host bloodstream. However, the QS signal" …
generate transmissible" stumpy forms" in their host bloodstream. However, the QS signal" …
Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of …
MD Urbaniak, DMA Martin… - Journal of proteome …, 2013 - ACS Publications
We report a global quantitative phosphoproteomic study of bloodstream and procyclic form
Trypanosoma brucei using SILAC labeling of each lifecycle stage. Phosphopeptide …
Trypanosoma brucei using SILAC labeling of each lifecycle stage. Phosphopeptide …