BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

STUDY QUESTION Is sperm epigenetic aging (SEA) associated with probability of
pregnancy among couples in the general population? SUMMARY ANSWER We observed a …

Delayed family planning and increased parental age increases the risk for infertility and
impaired offspring health. While the impact of ageing on oogenesis is well studied, on …

In brief Oxidative stress is recognized as an underlying driving factor of both telomere
dysfunction and human subfertility/infertility. This review briefly reassesses telomere integrity …

Background Spontaneous abortion is one of the prevalent adverse reproductive outcomes,
which seriously threatens maternal health around the world. Objective The current study is …

Advanced paternal age is associated with increased risks for reproductive and offspring
medical problems. Accumulating evidence suggests age-related changes in the sperm …

Normal spermatogenesis and sperm function are crucial for male fertility. The effects of
healthy testicular aging and testicular premature aging on spermatogenesis, sperm function …