Global warming, climate change, and environmental pollution: recipe for a multifactorial stress combination disaster

SI Zandalinas, FB Fritschi, R Mittler - Trends in Plant Science, 2021 - cell.com
Global warming, climate change, and environmental pollution present plants with unique
combinations of different abiotic and biotic stresses. Although much is known about how …

[HTML][HTML] Mitochondrial iron–sulfur clusters: Structure, function, and an emerging role in vascular biology

AD Read, RET Bentley, SL Archer, KJ Dunham-Snary - Redox biology, 2021 - Elsevier
Abstract Iron-sulfur (Fe–S) clusters are essential cofactors most commonly known for their
role mediating electron transfer within the mitochondrial respiratory chain. The Fe–S cluster …

The impact of multifactorial stress combination on plant growth and survival

SI Zandalinas, S Sengupta, FB Fritschi… - New …, 2021 - Wiley Online Library
Climate change‐driven extreme weather events, combined with increasing temperatures,
harsh soil conditions, low water availability and quality, and the introduction of many man …

Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression

S Sui, S Xu, D Pang - Pharmacology & therapeutics, 2022 - Elsevier
Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …

CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer

EH Kim, D Shin, J Lee, AR Jung, JL Roh - Cancer letters, 2018 - Elsevier
Sulfasalazine has been repurposed to induce ferroptotic cancer cell death via inhibition of
xc−-cystine/glutamate antiporter (xCT). However, cancer cells are capable of developing …

NEET proteins: a new link between iron metabolism, reactive oxygen species, and cancer

R Mittler, M Darash-Yahana, YS Sohn… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Cancer cells accumulate high levels of iron and reactive oxygen species
(ROS) to promote their high metabolic activity and proliferation rate. However, high levels of …

Iron: an essential element of cancer metabolism

MY Hsu, E Mina, A Roetto, PE Porporato - Cells, 2020 - mdpi.com
Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in
a hostile environment characterized by nutrient deprivation, poor vascularization and …

Redox-dependent gating of VDAC by mitoNEET

CH Lipper, JT Stofleth, F Bai, YS Sohn… - Proceedings of the …, 2019 - National Acad Sciences
MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation
of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human …

A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics

O Karmi, HB Marjault, F Bai, S Roy… - Proceedings of the …, 2022 - National Acad Sciences
Mitochondrial inner NEET (MiNT) and the outer mitochondrial membrane (OMM) mitoNEET
(mNT) proteins belong to the NEET protein family. This family plays a key role in …

Lessons learned from two decades of anticancer drugs

Z Liu, B Delavan, R Roberts, W Tong - Trends in pharmacological sciences, 2017 - cell.com
Tremendous efforts have been made to elucidate the basis of cancer biology with the aim of
promoting anticancer drug development. Especially over the past 20 years, anticancer drug …