Global warming, climate change, and environmental pollution: recipe for a multifactorial stress combination disaster
Global warming, climate change, and environmental pollution present plants with unique
combinations of different abiotic and biotic stresses. Although much is known about how …
combinations of different abiotic and biotic stresses. Although much is known about how …
[HTML][HTML] Mitochondrial iron–sulfur clusters: Structure, function, and an emerging role in vascular biology
Abstract Iron-sulfur (Fe–S) clusters are essential cofactors most commonly known for their
role mediating electron transfer within the mitochondrial respiratory chain. The Fe–S cluster …
role mediating electron transfer within the mitochondrial respiratory chain. The Fe–S cluster …
The impact of multifactorial stress combination on plant growth and survival
Climate change‐driven extreme weather events, combined with increasing temperatures,
harsh soil conditions, low water availability and quality, and the introduction of many man …
harsh soil conditions, low water availability and quality, and the introduction of many man …
Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression
S Sui, S Xu, D Pang - Pharmacology & therapeutics, 2022 - Elsevier
Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …
CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer
EH Kim, D Shin, J Lee, AR Jung, JL Roh - Cancer letters, 2018 - Elsevier
Sulfasalazine has been repurposed to induce ferroptotic cancer cell death via inhibition of
xc−-cystine/glutamate antiporter (xCT). However, cancer cells are capable of developing …
xc−-cystine/glutamate antiporter (xCT). However, cancer cells are capable of developing …
NEET proteins: a new link between iron metabolism, reactive oxygen species, and cancer
Significance: Cancer cells accumulate high levels of iron and reactive oxygen species
(ROS) to promote their high metabolic activity and proliferation rate. However, high levels of …
(ROS) to promote their high metabolic activity and proliferation rate. However, high levels of …
Iron: an essential element of cancer metabolism
MY Hsu, E Mina, A Roetto, PE Porporato - Cells, 2020 - mdpi.com
Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in
a hostile environment characterized by nutrient deprivation, poor vascularization and …
a hostile environment characterized by nutrient deprivation, poor vascularization and …
Redox-dependent gating of VDAC by mitoNEET
MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation
of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human …
of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human …
A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics
Mitochondrial inner NEET (MiNT) and the outer mitochondrial membrane (OMM) mitoNEET
(mNT) proteins belong to the NEET protein family. This family plays a key role in …
(mNT) proteins belong to the NEET protein family. This family plays a key role in …
Lessons learned from two decades of anticancer drugs
Tremendous efforts have been made to elucidate the basis of cancer biology with the aim of
promoting anticancer drug development. Especially over the past 20 years, anticancer drug …
promoting anticancer drug development. Especially over the past 20 years, anticancer drug …