We present a consolidated view of the complexity and challenges of designing studies for
measurement of energy metabolism in mouse models, including a practical guide to the …

Eating disorders (EDs) are serious psychiatric conditions influenced by biological,
psychological, and sociocultural factors. A better understanding of the genetics of these …

Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological
actions via activation of a family of G-protein-coupled receptors (GPCRs) known as …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

Abstract [This book presents] explanations of motivation, using an eclectic framework that
balances biological, behavioral, and cognitive theories. Not only are these theories …

As a result of superior efficacy and overall tolerability, atypical antipsychotic drugs have
become the treatment of choice for schizophrenia and related disorders, despite their side …

1 The effectiveness of antimuscarinic agents in the treatment of the overactive bladder (OAB)
syndrome is thought to arise through blockade of bladder muscarinic receptors located on …

Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …

Recent advances indicate that a robust physiologic system acts to maintain relative
constancy of weight in mammals. A key component of this system is leptin. Leptin is an …

Impaired functioning of pancreatic β cells is a key hallmark of type 2 diabetes. β cell function
is modulated by the actions of different classes of heterotrimeric G proteins. The functional …