Cardiovascular diseases (CVDs) comprise a group of disorders ranging from peripheral
artery, coronary artery, cardiac valve, cardiac muscle, and congenital heart diseases to …

MicroRNAs (miRNAs) are transcriptional and posttranscriptional regulators involved in
nearly all known biological processes in distant eukaryotic clades. Their discovery and …

CRISPR-Cas9 enables efficient sequence-specific mutagenesis for creating somatic or
germline mutants of model organisms. Key constraints in vivo remain the expression and …

Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In
adult mammalian hearts, most cardiomyocytes are terminally differentiated and have …

Preeclampsia (PE) is the leading cause of maternal and neonatal morbidity and mortality.
Defects in trophoblast invasion, differentiation of endovascular extravillous trophoblasts …

Heart development involves the precise orchestration of gene expression during cardiac
differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs …

Cardiac fibrosis is a hallmark in late-stage familial dilated cardiomyopathy (DCM) patients,
although the underlying mechanism remains elusive. Cardiac exosomes (Exos) have been …

The vertebrate heart develops from several progenitor lineages. After early-differentiating
first heart field (FHF) progenitors form the linear heart tube, late-differentiating second heart …

Pyridaben is a widely used acaricide in agriculture and reaches a high concentration (97
μg/L) in paddy water for a short time when pyridaben was applied to rice. However, its …

Significance: Cardiovascular disease (CVD) remains the major cause of morbidity and
mortality worldwide. Accumulating evidence indicates that atherosclerosis and its sequelae …