Bio-oriented synthesis of novel polyhydroquinoline derivatives as α-glucosidase inhibitor for management of diabetes
Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
Triazolothiadiazoles and triazolothiadiazines as potent α-glucosidase inhibitors: Mechanistic insights from kinetics studies, molecular docking and dynamics …
Diabetes mellitus has been considered as a serious health problem worldwide due its high
prevalence rate and associated complications. In this context, the current research work …
prevalence rate and associated complications. In this context, the current research work …
Meldrum-Based-1H-1,2,3-Triazoles as Antidiabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition Activity, Molecular Docking Studies, and In Silico Approach
A series of novel alkyl derivatives (2–5a, b) and 1 H-1, 2, 3-triazole analogues (7a–k) of
Meldrum's acid were synthesized in a highly effective way by using “click” chemistry and …
Meldrum's acid were synthesized in a highly effective way by using “click” chemistry and …
Synthesis of new diphenyl urea-clubbed imine analogs and its Implications in diabetic management through in vitro and in silico approaches
Type II diabetes mellitus (T2DM) is a global health issue with high rate of prevalence. The
inhibition of α-glucosidase enzyme has prime importance in the management of T2DM. This …
inhibition of α-glucosidase enzyme has prime importance in the management of T2DM. This …
Effect of Fe (III), Zn (II), and Cr (III) complexation on the physicochemical properties and bioactivities of corn silk polysaccharide
Y Jia, N Li, Q Wang, J Zhou, J Liu, M Zhang… - International Journal of …, 2021 - Elsevier
In this paper, Fe (III), Zn (II), and Cr (III) were used to complex with corn silk polysaccharide
(CSP) by classical methods and CSP-Fe, CSP-Zn, and CSP-Cr were successfully …
(CSP) by classical methods and CSP-Fe, CSP-Zn, and CSP-Cr were successfully …
Diaryl azo derivatives as anti-diabetic and antimicrobial agents: synthesis, in vitro, kinetic and docking studies
T Tahir, MI Shahzad, R Tabassum, M Rafiq… - Journal of Enzyme …, 2021 - Taylor & Francis
In the present study, a series of azo derivatives (TR-1 to TR-9) have been synthesised via
the diazo-coupling approach between substituted aromatic amines with phenol or naphthol …
the diazo-coupling approach between substituted aromatic amines with phenol or naphthol …
Synthesis of new phenoxymethylcoumarin clubbed 4-arylthiazolylhydrazines as α-glucosidase inhibitors and their kinetics and molecular docking studies
The current studies mainly demonstrate the coumarin based azomethine-clubbed thiazoles
synthesis and their in-vitro evaluation for the first time against α-glucosidase. Due to the …
synthesis and their in-vitro evaluation for the first time against α-glucosidase. Due to the …
Synthesis and biological evaluation of novel isatin-hydrazide conjugates as potential antidiabetic agents
Diabetes mellitus is a severe metabolic disorder, which has very high prevalence rate and
resulting into other health devastating complications. Pancreatic insulin resistance and-cell …
resulting into other health devastating complications. Pancreatic insulin resistance and-cell …
Identification of in vitro α-glucosidase and urease inhibitory effect, and in silico studies of Naproxen-derived 1, 3, 4-oxadiazole-based Schiff-base derivatives
In search of new α-glucosidase and urease inhibitors, a series of naproxen-derived 1, 3, 4-
oxadiazole-containing ketones 6a-e and their Schiff-base derivatives 7a-o were …
oxadiazole-containing ketones 6a-e and their Schiff-base derivatives 7a-o were …
Structural, dynamic behaviour, in-vitro and computational investigations of Schiff's bases of 1, 3-diphenyl urea derivatives against SARS-CoV-2 spike protein
The COVID-19 has had a significant influence on people's lives across the world. The viral
genome has undergone numerous unanticipated changes that have given rise to new …
genome has undergone numerous unanticipated changes that have given rise to new …