The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and
progression of various cancers. CCL2 can activate tumour cell growth and proliferation …

The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its
association with the progression of cancer. Although first described as a chemotactic …

Hypoxia is a key factor responsible for the failure of therapeutic response in most solid
tumors and promotes the acquisition of tumor resistance to various antitumor immune …

Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues
and can exhibit both tumoricidal and tumor-promoting activities. In 1989, we reported the …

Chemokines are involved in cellular interactions and tropism in situations frequently
associated with inflammation. Recently, the importance of chemokines and chemokine …

Malignant pleural effusion (MPE) is a common but serious condition that is related with poor
quality of life, morbidity and mortality. Its incidence and associated healthcare costs are …

Cell membrane–derived microparticles (MPs), the critical mediators of intercellular
communication, have gained much interest for use as natural drug delivery systems. Here …

Many proliferative, invasive, and immune tolerance mechanisms that support normal human
pregnancy are also exploited by malignancies to establish a nutrient supply and evade or …

The BRAF mutant, BRAFV600E, is expressed in nearly half of melanomas, and oral BRAF
inhibitors induce substantial tumor regression in patients with BRAFV600E metastatic …

Melanoma cells can enter the process of senescence, but whether they express a secretory
phenotype, as reported for other cells, is undetermined. This is of paramount importance …