Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
[HTML][HTML] Myrcene—what are the potential health benefits of this flavouring and aroma agent?
Myrcene (β-myrcene) is an abundant monoterpene which occurs as a major constituent in
many plant species, including hops and cannabis. It is a popular flavouring and aroma agent …
many plant species, including hops and cannabis. It is a popular flavouring and aroma agent …
[HTML][HTML] Cannabinoids and pain: new insights from old molecules
S Vučković, D Srebro, KS Vujović, Č Vučetić… - Frontiers in …, 2018 - frontiersin.org
Cannabis has been used for medicinal purposes for thousands of years. The prohibition of
cannabis in the middle of the 20th century has arrested cannabis research. In recent years …
cannabis in the middle of the 20th century has arrested cannabis research. In recent years …
[HTML][HTML] Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease
(CVD); however, little is known about the mechanism. Δ 9-tetrahydrocannabinol (Δ 9-THC) …
(CVD); however, little is known about the mechanism. Δ 9-tetrahydrocannabinol (Δ 9-THC) …
[HTML][HTML] Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex
Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders,
inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The …
inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The …
[HTML][HTML] CB2 receptor in microglia: the guardian of self-control
JA Komorowska-Müller, AC Schmöle - International journal of molecular …, 2020 - mdpi.com
Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …
[HTML][HTML] Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C (ut) annabinoid” System
The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted
homeostatic regulator, which influences a wide-variety of physiological processes all over …
homeostatic regulator, which influences a wide-variety of physiological processes all over …
Hepatic microcirculation and mechanisms of portal hypertension
J Gracia-Sancho, G Marrone… - Nature reviews …, 2019 - nature.com
The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …
Progress in brain cannabinoid CB2 receptor research: From genes to behavior
The type 2 cannabinoid receptor (CB2R) was initially regarded as a peripheral cannabinoid
receptor. However, recent technological advances in gene detection, alongside the …
receptor. However, recent technological advances in gene detection, alongside the …
[HTML][HTML] A guide to targeting the endocannabinoid system in drug design
A Stasiulewicz, K Znajdek, M Grudzień… - International journal of …, 2020 - mdpi.com
The endocannabinoid system (ECS) is one of the most crucial systems in the human
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …