A review of liposomes as a drug delivery system: current status of approved products, regulatory environments, and future perspectives

P Liu, G Chen, J Zhang - Molecules, 2022 - mdpi.com
Liposomes have been considered promising and versatile drug vesicles. Compared with
traditional drug delivery systems, liposomes exhibit better properties, including site …

The enhanced permeability and retention (EPR) effect: the significance of the concept and methods to enhance its application

J Wu - Journal of personalized medicine, 2021 - mdpi.com
Chemotherapy for human solid tumors in clinical practice is far from satisfactory. Despite the
discovery and synthesis of hundreds of thousands of anticancer compounds targeting …

The exit of nanoparticles from solid tumours

LNM Nguyen, ZP Lin, S Sindhwani, P MacMillan… - Nature Materials, 2023 - nature.com
Nanoparticles enter tumours through endothelial cells, gaps or other mechanisms, but how
they exit is unclear. The current paradigm states that collapsed tumour lymphatic vessels …

Bioorthogonal chemistry and its applications

RE Bird, SA Lemmel, X Yu, QA Zhou - Bioconjugate Chemistry, 2021 - ACS Publications
Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional
groups to explore and understand biology in living organisms. In this review, we summarize …

Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance

Y Yao, Y Zhou, L Liu, Y Xu, Q Chen, Y Wang… - Frontiers in molecular …, 2020 - frontiersin.org
Nanotechnology has been extensively studied and exploited for cancer treatment as
nanoparticles can play a significant role as a drug delivery system. Compared to …

Emerging applications of nanotechnology in healthcare and medicine

S Malik, K Muhammad, Y Waheed - Molecules, 2023 - mdpi.com
Knowing the beneficial aspects of nanomedicine, scientists are trying to harness the
applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There …

[HTML][HTML] Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and …

Y Lu, Q Luo, X Jia, JP Tam, H Yang, Y Shen… - Journal of Pharmaceutical …, 2023 - Elsevier
Flavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii
Folium (EF) and possess excellent therapeutic effects on various diseases. Encouragingly …

Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms

Y Zi, K Yang, J He, Z Wu, J Liu, W Zhang - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …

[HTML][HTML] Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components

R Augustine, A Hasan, R Primavera, RJ Wilson… - Materials Today …, 2020 - Elsevier
The utilization of nanomaterials in the biological and medical field is quickly progressing,
particularly in areas where traditional diagnostics and treatment approaches have limited …

Tumor-targeted cascade nanoreactor based on metal–organic frameworks for synergistic ferroptosis–starvation anticancer therapy

X Wan, L Song, W Pan, H Zhong, N Li, B Tang - ACS nano, 2020 - ACS Publications
Although ferroptosis therapy has been proven to be a promising strategy for cancer
treatment, its efficacy still might be limited by insufficient H2O2 supply in tumor tissue …