A mechanistic stochastic framework for regulating bacterial cell division

KR Ghusinga, CA Vargas-Garcia, A Singh - Scientific reports, 2016 - nature.com
How exponentially growing cells maintain size homeostasis is an important fundamental
problem. Recent single-cell studies in prokaryotes have uncovered the adder principle …

Estimation of mean first passage time for bursty gene expression

M Shreshtha, A Surendran, A Ghosh - Physical biology, 2016 - iopscience.iop.org
Gene expression is an intrinsically noisy process, typically, producing mRNAs and proteins
in bursts. An important description of such stochastic processes can be done in terms of the …

Switches in a genetic regulatory system under multiplicative non-Gaussian noise

X Chen, YM Kang, YX Fu - Journal of Theoretical Biology, 2017 - Elsevier
The non-Gaussian noise is multiplicatively introduced to model the universal fluctuation in
the gene regulation of the bacteriophage λ. To investigate the key effect of non-Gaussian …

Effect of gene-expression bursts on stochastic timing of cellular events

KR Ghusinga, A Singh - 2017 American Control Conference …, 2017 - ieeexplore.ieee.org
Gene expression is inherently a noisy process which manifests as cell-to-cell variability in
time evolution of proteins. Consequently, events that trigger at critical threshold levels of …

Theoretical predictions on the first-passage time for a gene expression model

KR Ghusinga, A Singh - 2015 54th IEEE Conference on …, 2015 - ieeexplore.ieee.org
Expression of a gene is inherently random, leading to variability in a protein's level across a
population of cells with same genetic information and environment. Another consequence of …

Noise mechanisms in synaptic transmission and their impact on spike-timing precision

A Singh - 2017 IEEE 56th Annual Conference on Decision and …, 2017 - ieeexplore.ieee.org
In the nervous system, communication occurs via synaptic transmission where signaling
molecules (neurotransmitters) are released by the presynaptic neuron, and they influence …

[HTML][HTML] Block-tridiagonal state-space realization of Chemical Master Equations: A tool to compute explicit solutions

A Borri, F Carravetta, G Mavelli, P Palumbo - Journal of Computational and …, 2016 - Elsevier
Abstract Chemical Master Equations (CMEs) provide a comprehensive way to model the
probabilistic behavior in biochemical networks. Despite their widespread diffusion in …

Optimal regulation of protein degradation to schedule cellular events with precision

KR Ghusinga, A Singh - 2016 American Control Conference …, 2016 - ieeexplore.ieee.org
An important event in many cellular contexts is the crossing of a prescribed threshold by a
regulatory protein. The timing of such events is stochastic as a consequence of the innate …

Optimal auto-regulation to minimize first-passage time variability in protein level

KR Ghusinga, PW Fok, A Singh - 2015 American Control …, 2015 - ieeexplore.ieee.org
The timing of cellular events is inherently random because of the probabilistic nature of gene
expression. Yet cells manage to have precise timing of important events. Here, we study …

Modeling noise mechanisms in neuronal synaptic transmission

A Singh - bioRxiv, 2017 - biorxiv.org
In the nervous system, communication occurs via synaptic transmission where signaling
molecules (neurotransmitters) are released by the presynaptic neuron, and they influence …