A mechanistic stochastic framework for regulating bacterial cell division
How exponentially growing cells maintain size homeostasis is an important fundamental
problem. Recent single-cell studies in prokaryotes have uncovered the adder principle …
problem. Recent single-cell studies in prokaryotes have uncovered the adder principle …
Estimation of mean first passage time for bursty gene expression
Gene expression is an intrinsically noisy process, typically, producing mRNAs and proteins
in bursts. An important description of such stochastic processes can be done in terms of the …
in bursts. An important description of such stochastic processes can be done in terms of the …
Switches in a genetic regulatory system under multiplicative non-Gaussian noise
X Chen, YM Kang, YX Fu - Journal of Theoretical Biology, 2017 - Elsevier
The non-Gaussian noise is multiplicatively introduced to model the universal fluctuation in
the gene regulation of the bacteriophage λ. To investigate the key effect of non-Gaussian …
the gene regulation of the bacteriophage λ. To investigate the key effect of non-Gaussian …
Effect of gene-expression bursts on stochastic timing of cellular events
KR Ghusinga, A Singh - 2017 American Control Conference …, 2017 - ieeexplore.ieee.org
Gene expression is inherently a noisy process which manifests as cell-to-cell variability in
time evolution of proteins. Consequently, events that trigger at critical threshold levels of …
time evolution of proteins. Consequently, events that trigger at critical threshold levels of …
Theoretical predictions on the first-passage time for a gene expression model
KR Ghusinga, A Singh - 2015 54th IEEE Conference on …, 2015 - ieeexplore.ieee.org
Expression of a gene is inherently random, leading to variability in a protein's level across a
population of cells with same genetic information and environment. Another consequence of …
population of cells with same genetic information and environment. Another consequence of …
Noise mechanisms in synaptic transmission and their impact on spike-timing precision
A Singh - 2017 IEEE 56th Annual Conference on Decision and …, 2017 - ieeexplore.ieee.org
In the nervous system, communication occurs via synaptic transmission where signaling
molecules (neurotransmitters) are released by the presynaptic neuron, and they influence …
molecules (neurotransmitters) are released by the presynaptic neuron, and they influence …
[HTML][HTML] Block-tridiagonal state-space realization of Chemical Master Equations: A tool to compute explicit solutions
Abstract Chemical Master Equations (CMEs) provide a comprehensive way to model the
probabilistic behavior in biochemical networks. Despite their widespread diffusion in …
probabilistic behavior in biochemical networks. Despite their widespread diffusion in …
Optimal regulation of protein degradation to schedule cellular events with precision
KR Ghusinga, A Singh - 2016 American Control Conference …, 2016 - ieeexplore.ieee.org
An important event in many cellular contexts is the crossing of a prescribed threshold by a
regulatory protein. The timing of such events is stochastic as a consequence of the innate …
regulatory protein. The timing of such events is stochastic as a consequence of the innate …
Optimal auto-regulation to minimize first-passage time variability in protein level
The timing of cellular events is inherently random because of the probabilistic nature of gene
expression. Yet cells manage to have precise timing of important events. Here, we study …
expression. Yet cells manage to have precise timing of important events. Here, we study …
Modeling noise mechanisms in neuronal synaptic transmission
A Singh - bioRxiv, 2017 - biorxiv.org
In the nervous system, communication occurs via synaptic transmission where signaling
molecules (neurotransmitters) are released by the presynaptic neuron, and they influence …
molecules (neurotransmitters) are released by the presynaptic neuron, and they influence …