Drug delivery systems are molecular platforms in which an active compound is packed into
or loaded on a biocompatible nanoparticle. Such a solution improves the activity of the …

Incorporating labile bonds inside polymer backbone and side chains yields interesting
polymer materials that are responsive to change of environmental stimuli. Drugs can be …

Multidrug resistance (MDR), defined as the ability of cancer cells to gain resistance to both
conventional and novel chemotherapy agents, is an important barrier in treating …

Different mechanisms in cancer cells become resistant to one or more chemotherapeutics is
known as multidrug resistance (MDR) which hinders chemotherapy efficacy. Potential …

Stimuli-controlled drug delivery and release is of great significance in cancer therapy,
making a stimuli-responsive drug carrier highly demanded. Herein, a multistimuli-controlled …

Aptamers are single-stranded RNA or DNA ligands that can specifically bind to various
molecular targets with high affinity. Owing to this unique character, they have become …

Effective targeting drug delivery system for glioma treatment is still greatly challenged by the
existence of the blood–brain barrier (BBB) and the intracranial overspreading of anti-tumor …

The application of doxorubicin (DOX) and methotrexate (MTX) delivery, like other anticancer
drugs, is limited by insufficient targeting to cancerous tissue cells. The development of smart …

The selection of technological parameters for nanoparticle formulation represents a
complicated development phase. Therefore, the statistical analysis based on Box–Behnken …

Abstract Poly-l-lysine (PLL) dendrimers are currently being investigated as antiangiogenic
agent for therapy of cancer. In this study, we report folate conjugated poly-l-lysine …