Functions of circular RNA in human diseases and illnesses

A Gu, DK Jaijyan, S Yang, M Zeng, S Pei, H Zhu - Non-coding RNA, 2023 - mdpi.com
Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently
closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free …

Viral circular RNAs and their possible roles in virus-host interaction

X Zhang, Z Liang, C Wang, Z Shen, S Sun… - Frontiers in …, 2022 - frontiersin.org
Circular RNAs (circRNAs) as novel regulatory molecules have been recognized in diverse
species, including viruses. The virus-derived circRNAs play various roles in the host …

BmNPV circular RNA-encoded peptide VSP39 promotes viral replication

Y Zhang, X Zhang, Z Shen, Q Qiu, X Tong, J Pan… - International Journal of …, 2023 - Elsevier
CircRNAs are covalently closed single-stranded circular RNA molecules, which are not
easily degraded by endonucleases and play vital roles in many biological processes …

Competing endogenous RNA network mediated by circ_3205 in SARS-CoV-2 infected cells

D Barbagallo, CI Palermo, C Barbagallo… - Cellular and Molecular …, 2022 - Springer
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new
member of the Betacoronaviridae family, responsible for the recent pandemic outbreak of …

New insights on circular RNAs and their potential applications as biomarkers, therapeutic agents, and preventive vaccines in viral infections: with a glance at SARS …

N Rahmani-Kukia, A Abbasi - Molecular Therapy-Nucleic Acids, 2022 - cell.com
The occurrence of viral infections and approaches to handling them are very challenging
and require prompt diagnosis and timely treatment. Recently, genomic medicine …

Circular RNAs represent a novel class of human cytomegalovirus transcripts

S Yang, X Liu, M Wang, D Cao, DK Jaijyan… - Microbiology …, 2022 - Am Soc Microbiol
Human cytomegalovirus (HCMV) infects a large portion of the human population globally.
Several HCMV-derived noncoding RNAs are involved in the regulation of viral gene …

Micropeptide vsp21 translated by Reovirus circular RNA 000048 attenuates viral replication

Y Zhang, M Zhu, X Zhang, K Dai, Z Liang, J Pan… - International Journal of …, 2022 - Elsevier
To date, some DNA viruses and single-stranded RNA viruses have been found to generate
circRNAs. However, the reports on circRNAs produced by double-stranded RNA viruses are …

Past, present and future: the relationship between circular RNA and immunity

J Gu, C Su, F Huang, Y Zhao, J Li - Frontiers in Immunology, 2022 - frontiersin.org
The immune system has evolved since the birth of humans. However, immune-related
diseases have not yet been overcome due to the lack of expected indicators and targeting …

Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression

X Gao, D Fang, Y Liang, X Deng, N Chen… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19), an infectious acute respiratory disease caused by a
newly emerging RNA virus, is a still-growing pandemic that has caused more than 6 million …

Harringtonine: A more effective antagonist for Omicron variant

S Hu, N Wang, S Chen, H Zhang, C Wang, W Ma… - Biochemical …, 2023 - Elsevier
Fusion with host cell membrane is the main mechanism of infection of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we propose that a new strategy to …