Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans
CK Cheng, PCK Leung - Endocrine reviews, 2005 - academic.oup.com
In human beings, two forms of GnRH, termed GnRH-I and GnRH-II, encoded by separate
genes have been identified. Although these hormones share comparable cDNA and …
genes have been identified. Although these hormones share comparable cDNA and …
Protecting ovaries during chemotherapy through gonad suppression: a systematic review and meta-analysis
E Elgindy, H Sibai, A Abdelghani… - Obstetrics & …, 2015 - journals.lww.com
OBJECTIVE: To estimate whether gonadotropin-releasing hormone (GnRH) analog
administration during chemotherapy can protect against development of ovarian toxicity …
administration during chemotherapy can protect against development of ovarian toxicity …
Clinical correlation of apoptosis in human granulosa cells—a review
CP Almeida, MCF Ferreira, CO Silveira… - Cell biology …, 2018 - Wiley Online Library
The quality of oocytes depends on interactions with surrounding granulosa cells. Granulosa
cells are essential in normal follicular maturation process since they produce steroidal …
cells are essential in normal follicular maturation process since they produce steroidal …
GnRH in non-hypothalamic reproductive tissues
N Ramakrishnappa, R Rajamahendran, YM Lin… - Animal reproduction …, 2005 - Elsevier
Gonadotropin releasing hormone (GnRH) is a hypothalamic neuronal secretory decapeptide
that plays a pivotal role in mammalian reproduction. GnRH and its analogues are used …
that plays a pivotal role in mammalian reproduction. GnRH and its analogues are used …
Life and death of female gametes during oogenesis and folliculogenesis
DV Krysko, A Diez-Fraile, G Criel, AA Svistunov… - Apoptosis, 2008 - Springer
The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles
are rapidly and effectively eliminated early in ontogeny and thereafter continuously …
are rapidly and effectively eliminated early in ontogeny and thereafter continuously …
Multi-factorial role of GnRH-I and GnRH-II in the human ovary
PCK Leung, CK Cheng, XM Zhu - Molecular and Cellular Endocrinology, 2003 - Elsevier
Normal ovarian functions are regulated by a wide variety of endocrine hormones, local
paracrine and autocrine factors, which functionally interact with each other in a highly …
paracrine and autocrine factors, which functionally interact with each other in a highly …
Immunolocalization of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and type I GnRH receptor during follicular development in the human ovary
JH Choi, CB Gilks, N Auersperg… - The Journal of Clinical …, 2006 - academic.oup.com
Context: GnRH and its receptor have been detected at the mRNA level in different ovarian
cell types, implicating an autocrine role of the GnRH system in the human ovary. However …
cell types, implicating an autocrine role of the GnRH system in the human ovary. However …
Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5
Y Kitajima, T Endo, K Nagasawa, K Manase… - …, 2006 - academic.oup.com
We investigated the mechanism by which a GnRH agonist (GnRHa) affects ovarian
vascularity, vascular permeability, and expression of the tight junction protein claudin-5 in a …
vascularity, vascular permeability, and expression of the tight junction protein claudin-5 in a …
Neuropeptides in the gonads: from evolution to pharmacology
NL McGuire, GE Bentley - Frontiers in Pharmacology, 2010 - frontiersin.org
Vertebrate gonads are the sites of synthesis and binding of many peptides that were initially
classified as neuropeptides. These gonadal neuropeptide systems are neither well …
classified as neuropeptides. These gonadal neuropeptide systems are neither well …
Gonadotropin-releasing hormone in the ovary
C Metallinou, B Asimakopoulos… - Reproductive …, 2007 - journals.sagepub.com
Gonadotropin-releasing hormone (GnRH) plays a pivotal role in the physiology of
reproduction in mammals. GnRH acts by binding to the GnRH receptor (GnRHR). In …
reproduction in mammals. GnRH acts by binding to the GnRH receptor (GnRHR). In …