Compulsivity is associated with alterations in the structure and the function of parallel and
interacting brain circuits involved in emotional processing (involving both the reward and the …

Functional imaging studies have reported with remarkable consistency hyperactivity in the
orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and caudate nucleus of patients …

There has been little analysis of neurochemical correlates of compulsive behaviour to
illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance …

The measurement of brain metabolites with magnetic resonance spectroscopy (MRS)
provides a unique perspective on the brain bases of neuropsychiatric disorders. As a context …

Context The medial frontal cortex (MFC), including the dorsal anterior cingulate and the
supplementary motor area, is critical for adaptive and inhibitory control of behavior …

Background Previous neuroimaging studies of obsessive-compulsive disorder (OCD) have
reported both baseline functional alterations and pharmacological changes in localized …

The most prevalent mental disorders, anxiety and mood disorders, are associated with both
functional and morphological brain changes that commonly involve the 'fear …

Functional neuroimaging studies have converged to suggest that cortico-striatal-thalamo-
cortical (CSTC) circuit dysfunction is a core pathophysiologic feature of obsessive …

Background: Obsessive–compulsive disorder (OCD) is a common neuropsychiatric disorder
that is characterized by recurrent intrusive thoughts, ideas or images and repetitive ritualistic …

The potential role of white matter (WM) abnormalities in the pathophysiology of obsessive
compulsive disorder (OCD) is substantially unexplored. Apart from alterations in the WM …