Mechanisms of autoantibody-induced pathology
RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
Graves' disease
TF Davies, S Andersen, R Latif, Y Nagayama… - Nature reviews Disease …, 2020 - nature.com
Graves' disease (GD) is an autoimmune disease that primarily affects the thyroid gland. It is
the most common cause of hyperthyroidism and occurs at all ages but especially in women …
the most common cause of hyperthyroidism and occurs at all ages but especially in women …
Structures of full-length glycoprotein hormone receptor signalling complexes
Luteinizing hormone and chorionic gonadotropin are glycoprotein hormones that are related
to follicle-stimulating hormone and thyroid-stimulating hormone,. Luteinizing hormone and …
to follicle-stimulating hormone and thyroid-stimulating hormone,. Luteinizing hormone and …
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
During HIV-1 infection, antibodies are generated against the region of the viral gp120
envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these …
envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these …
Hormone-and antibody-mediated activation of the thyrotropin receptor
Abstract Thyroid-stimulating hormone (TSH), through activation of its G-protein-coupled
thyrotropin receptor (TSHR), controls the synthesis of thyroid hormone—an essential …
thyrotropin receptor (TSHR), controls the synthesis of thyroid hormone—an essential …
Clinical utility of TSH receptor antibodies
G Barbesino, Y Tomer - The Journal of Clinical Endocrinology & …, 2013 - academic.oup.com
Context: TSH receptor antibodies (TRAb) cause Graves' disease (GD) hyperthyroidism.
Widely available TRAb measurement methods have been significantly improved recently …
Widely available TRAb measurement methods have been significantly improved recently …
Autoantibody mimicry of hormone action at the thyrotropin receptor
Thyroid hormones are vital in metabolism, growth and development. Thyroid hormone
synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR). In …
synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR). In …
Thyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to …
SM McLachlan, B Rapoport - Thyroid, 2013 - liebertpub.com
Background: Thyrotropin receptor (TSHR) antibodies that stimulate the thyroid (TSAb) cause
Graves' hyperthyroidism and TSHR antibodies which block thyrotropin action (TBAb) are …
Graves' hyperthyroidism and TSHR antibodies which block thyrotropin action (TBAb) are …
Autoantibodies as endogenous modulators of GPCR signaling
MA Skiba, AC Kruse - Trends in pharmacological sciences, 2021 - cell.com
Endogenous self-reactive autoantibodies (AAs) recognize a range of G-protein-coupled
receptors (GPCRs). They are frequently associated with cardiovascular, neurological, and …
receptors (GPCRs). They are frequently associated with cardiovascular, neurological, and …
Graves' disease mechanisms: the role of stimulating, blocking, and cleavage region TSH receptor antibodies
SA Morshed, TF Davies - Hormone and Metabolic Research, 2015 - thieme-connect.com
The immunologic processes involved in Graves' disease (GD) have one unique
characteristic–the autoantibodies to the TSH receptor (TSHR)–which have both linear and …
characteristic–the autoantibodies to the TSH receptor (TSHR)–which have both linear and …