A global catalog of whole-genome diversity from 233 primate species

LFK Kuderna, H Gao, MC Janiak, M Kuhlwilm, JD Orkin… - Science, 2023 - science.org
The rich diversity of morphology and behavior displayed across primate species provides an
informative context in which to study the impact of genomic diversity on fundamental …

TMPRSS2 polymorphism (rs12329760) and the severity of the COVID-19 in Iranian population

A Yaghoobi, JS Lord, JS Rezaiezadeh… - PLoS …, 2023 - journals.plos.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been responsible for
the recent pandemic since early 2020. Due to the wide range of clinical symptoms of this …

Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic review

J Li, Y Wang, Y Liu, Z Zhang, Y Zhai, Y Dai… - European Journal of …, 2022 - Springer
Objective To determine the effect of polymorphisms and mutations in angiotensin-converting
enzyme 2 (ACE2) and Type 2 transmembrane serine proteases (TMPRSS2) genes on …

[HTML][HTML] Potential genes associated with COVID-19 and comorbidity

S Feng, F Song, W Guo, J Tan, X Zhang… - … journal of medical …, 2022 - ncbi.nlm.nih.gov
Hypertension, diabetes mellitus, and coronary artery disease are common comorbidities and
dangerous factors for infection and serious COVID-19. Polymorphisms in genes associated …

Viral and host genetic and epigenetic biomarkers related to SARS-CoV-2 cell entry, infection rate, and disease severity

J Gaspersic, V Dolzan - Biology, 2022 - mdpi.com
Simple Summary COVID-19 emerged as a new disease with quick transmission and a high
mortality rate at the end of 2019, caused by SARS-CoV-2. Common features of the …

[HTML][HTML] Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in …

O Izmailova, O Shlykova, A Kabaliei… - Acta Bio Medica …, 2023 - ncbi.nlm.nih.gov
Methods: The study population consisted of the Ukrainian population with COVID-19:
patients without oxygen therapy (n= 62), with non-invasive (n= 92) and invasive (n= 35) …

In plain sight: the role of alpha-1-antitrypsin in COVID-19 pathogenesis and therapeutics.

KY Oguntuyo, CS Stevens, MN Siddiquey… - Biorxiv: the Preprint …, 2020 - europepmc.org
Entry of SARS-CoV-2 is facilitated by endogenous and exogenous proteases. These
proteases proteolytically activate the SARS-CoV-2 spike glycoprotein and are key …

Distinct evolutionary trajectories of SARS-CoV-2-interacting proteins in bats and primates identify important host determinants of COVID-19

M Cariou, L Picard, L Guéguen… - Proceedings of the …, 2022 - National Acad Sciences
The coronavirus disease 19 (COVID-19) pandemic is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), a coronavirus that spilled over from the bat …

The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes

LE Martínez-Gómez, C Martinez-Armenta… - Frontiers in …, 2024 - frontiersin.org
Introduction Serine proteases play a critical role during SARS-CoV-2 infection. Therefore,
polymorphisms of transmembrane protease serine 2 (TMPRSS2) and serpine family E …

[HTML][HTML] ACE2 and TMPRSS2 polymorphisms and the development of COVID-19: A review of the literature

AA da Silva Oliveira, AMP da Silva… - … Journal of Clinical …, 2022 - clinvirologyjournal.com
SARS-CoV-2 is a virus that has a positive-sense, single-stranded RNA genome that
encodes 4 structural proteins, the main one being the S protein (Spike) responsible for …