Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response
to viral infections. In response to viral stimuli, cells produce and release interferons, which …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Gene expression is regulated by transcription factors (TFs), proteins that recognize short
DNA sequence motifs,,. Such sequences are very common in the human genome, and an …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Highlights•Transcription factors can cooperate with each other via multiple mechanisms that
have different specificities and ranges.•Cooperativity can result from direct protein–protein …

Inflammation is an essential response provided by the immune systems that ensures the
survival during infection and tissue injury. Inflammatory responses are essential for the …

Targeted protein degradation approaches have been widely used for degrading oncogenic
proteins, providing a potentially promising therapeutic strategy for cancer treatment …

Large-scale human genetic data,–have shown that cancer mutations display strong tissue-
selectivity, but how this selectivity arises remains unclear. Here, using experimental models …

Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, and dendritic cell
differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU. 1 or …

Transcriptional activation of the interferon-β (IFN-β) gene requires assembly of an
enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFκB. These factors bind …