Background The context-sensitive half-time, rather than the terminal elimination half-life, has
been proposed as a more clinically relevant measure of decreasing drug concentration after …

Background Intrathecal administration of morphine produces intense analgesia, but it
depresses respiration, an effect that can be life-threatening. Whether intrathecal morphine …

Background Remifentanil is a new opioid with properties similar to other mu-specific
agonists. To establish its pharmacologic profile relative to other known opioids, it is …

Epidural anesthesia may impair pulmonary ventilation in elderly people. We examined the
effects of lumbar or thoracic epidural anesthesia on resting ventilation, arterial blood gas …

Background. Opioid overdose is an increasing health problem worldwide. The
cardiovascular toxicity of opioids contributes to morbidity and mortality in overdose but the …

The eflect of lumbar or thoracic extradurul anaesthesia on the ventilatory response to
progressive isocapnic hypoxaemia was studied in two groups of 10 unpremeditated …

We have described the pharmacology of four short-acting μ opioid agonists which are being
investigated for possible use in anaesthesia. Most of them are typical opioids which retain all …

The purpose of our randomized, double-blind study of 64 unpremedicated healthy patients
undergoing surgical procedures with a duration of at least 60 min was to compare 0.75 μg …

Opioids are widely used in anaesthesia. Advances in our understanding of the endogenous
opioid system have provided a rational explanation of how opioids work. Opioids form a …

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