Cilia and mitotic spindles are microtubule (MT)-based, macromolecular machines that
consecutively assemble and disassemble during interphase and M phase of the cell cycle …

The primary cilium is a conserved microtubule-based organelle that is critical for transducing
developmental, sensory and homeostatic signaling pathways. It comprises an axoneme with …

Cilia are essential organelles that protrude from the cell body. Cilia are made of a
microtubule-based structure called the axoneme. In most types of cilia, the ciliary tip is …

Cilia build distinct subdomains with variable axonemal structures to perform diverse
functions in cell motility and signaling. In sensory cilia across species, an axoneme …

Cilia are cellular projections that perform sensory and motile functions in eukaryotic cells. A
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …

Joubert syndrome (JBTS) is a recessive neurodevelopmental ciliopathy characterized by a
pathognomonic hindbrain malformation. All known JBTS genes encode proteins involved in …

Flagellar assembly depends on intraflagellar transport (IFT), a bidirectional motility of protein
carriers, the IFT trains. The trains are periodic assemblies of IFT-A and IFT-B subcomplexes …

Eukaryotic cilia are microtubule-based organelles that protrude from the cell surface to fulfill
sensory and motility functions. Their basic structure consists of an axoneme templated by a …

CEP104 is an evolutionarily conserved centrosomal and ciliary tip protein. CEP104 loss-of-
function mutations are reported in patients with Joubert syndrome, but their function in the …

Ciliates are a powerful model organism for the study of basal bodies and motile cilia. These
single-celled protists contain hundreds of cilia organized in an array making them an ideal …