The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

Reactive oxygen species (ROS) are generated in the plants during cellular metabolism. But
extreme environmental conditions like drought, salinity or floods etc. lead to an enhanced …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

The metabolic heterogeneity and metabolic interplay between cells are known as significant
contributors to disease treatment resistance. However, with the lack of a mature high …

The growing incidence of melanoma is a serious public health issue that merits a thorough
understanding of potential causative risk factors, which includes exposure to ultraviolet …

Significance: Human apurinic/apyrimidinic endonuclease 1 (APE1, also known as REF-1)
was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding …

Before a deleterious DNA lesion can be replaced with its undamaged counterpart, the lesion
must first be removed from the genome. This process of removing and replacing DNA …

Solar UVB is carcinogenic. Nucleotide excision repair (NER) counteracts the carcinogenicity
of UVB by excising potentially mutagenic UVB-induced DNA lesions. Despite this capacity …

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A
growing body of evidence indicates that tumors accumulate progressively more mutations in …